Identification of immune-related lncRNAs in periodontitis reveals regulation network of gene-lncRNA-pathway-immunocyte.

Long noncoding RNAs (lncRNAs), which is essential in regulating multiple biological functions, have been found to have pivotal roles in immune regulation. Since immune reaction and immunocytes are the key part in periodontitis progression, we aim to investigate the underlying lncRNA-immunity regulatory network of periodontitis.A series of bioinformatic algorithms were used to identify immune-related lncRNAs in periodontitis. Infiltrating immunocyte were calculated by MCP-count. Pathway activity were estimated by the GSVA. The relationships between immune-related lncRNA and periodontitis features were investigated including immune gene categories, perturbated lncRNAs, immunocytes and pathways. Immune-related periodontitis subtypes were identified by ConsensusClusterPlus algorithm. Immunocytes related gene-lncRNA modules were identified by WGCNA.An integrated algorithm and pipeline to identify immune-related lncRNAs was developed and 1059 immune-related lncRNAs in 14 immune categories were identified, 291 of them were perturbated in periodontitis. An independent validation set verified the robustness of immune-related lncRNAs. A higher proportion of immune-related lncRNAs are correlated with immunocyte infiltration.

KT 5720
B9002-.5 500 µg
EUR 818

KT 5823
B6673-.05 50 µg
EUR 123

KT 5823
B6673-.1 100 µg
EUR 190

KT 5823
B6673-.25 250 µg
EUR 361

PST- KT
PVT11358 2 ug
EUR 370

mmu-miR-6945-3p Primers
MPM01702 150 ul / 10 uM
EUR 121

mmu-miR-6945-5p Primers
MPM01703 150 ul / 10 uM
EUR 121

mmu-miR-6945-3p miRNA Inhibitor
MIM02638 2 x 5.0 nmol
EUR 176

mmu-miR-6945-5p miRNA Inhibitor
MIM02639 2 x 5.0 nmol
EUR 176

mmu-miR-6945-3p miRNA Antagomir
MNM02638 2 x 5.0 nmol
EUR 329

mmu-miR-6945-5p miRNA Antagomir
MNM02639 2 x 5.0 nmol
EUR 329

Plasminogen Receptor (KT) (PLGRKT) Antibody
20-abx318476
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

KT 5823 (PKG kinase inhibitor)
SIH-458-100UG 100 µg
EUR 205
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)
SIH-458-500UG 500 µg
EUR 569
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

S- Adenosylhomocysteine Antibody (Clone # 301-10)
6945-25
EUR 218

LRRC37A3 Blocking Peptide
33R-6945 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LRRC37A3 antibody, catalog no. 70R-7010

FMR1 antibody
10R-6945 100 ul
EUR 726
Description: Mouse monoclonal FMR1 antibody

PPAPDC2 antibody
70R-6945 50 ug
EUR 467
Description: Rabbit polyclonal PPAPDC2 antibody raised against the N terminal of PPAPDC2

DDX60 Antibody
6945-002mg 0.02 mg
EUR 171.82
Description: DDX60 Antibody: DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.

DDX60 Antibody
6945-01mg 0.1 mg
EUR 436.42
Description: DDX60 Antibody: DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-48T 48T
EUR 317

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-96T 96T
EUR 496

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E11201 96T
EUR 361

Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E20317 96T
EUR 361

Factor XI Antibody Pair
55R-FAC11-KT 5 plates
EUR 745
Description: Factor XI antigen Matched Pair antibody Set for ELISA

Factor IX Antibody Pair
55R-FAC9-KT 5 plates
EUR 760
Description: Factor IX antigen Matched Pair antibody Set for ELISA

Fibrinogen Matched Pair antibody Set
55R-FIBRINO-KT set
EUR 833
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory

Mouse RANKL ELISA Kit
55R-MRANKL-KT 1 kit
EUR 658
Description: ELISA kit for detection of Mouse RANKL in the research laboratory

VWF Antibody Pair
55R-VWF-KT 5 plates
EUR 775
Description: VWF antigen Matched Pair antibody Set for ELISA