Protein promiscuity in drug discovery, drug-repurposing and antibiotic resistance.

Proteins are supposed to bind to their substrates/ligands in a specific manner via their pre-formed binding sites, according to classical biochemistry. In recent years, several types of deviations from this norm have been observed and called promiscuous behavior. Enzymatic promiscuities allow several biochemical functions to be carried out by the same enzyme. The promiscuous activity can also be the origin of “new proteins” via gene duplication. In more recent years, proteins from prokaryotes, eukaryotes and viruses have been found to have intrinsic disorder and lack a preformed binding site. Intrinsic disorder is exploited in regulatory proteins such as those that are involved in transcription and signal transduction.

KT 5720
B9002-.5 500 µg
EUR 818

KT 5823
B6673-.05 50 µg
EUR 123

KT 5823
B6673-.1 100 µg
EUR 190

KT 5823
B6673-.25 250 µg
EUR 361

PST- KT
PVT11358 2 ug
EUR 370

gp100 (619–627)
5-01246 4 x 5mg Ask for price

gp100 (619-627) Peptide
20-abx266111
  • EUR 411.00
  • EUR 662.00
  • EUR 314.00
  • 10 mg
  • 25 mg
  • 5 mg

Gab1 (Ab-627) Antibody
21283-100ul 100ul
EUR 252

Gab1 (Ab-627) Antibody
21283-50ul 50ul
EUR 187

GAB1 (Ab-627) Antibody
CSB-PA582871-
EUR 335
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

GAB1 (Ab-627) Antibody
CSB-PA582871-100ul 100ul
EUR 316
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

anti-Gab1 (Ab-627)
LF-PA20172 100 ul
EUR 334
Description: Rabbit polyclonal to Gab1

hsa-miR-627 Primers
MPH01927 150 ul / 10 uM
EUR 121

Plasminogen Receptor (KT) (PLGRKT) Antibody
20-abx318476
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

KT 5823 (PKG kinase inhibitor)
SIH-458-100UG 100 µg
EUR 205
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)
SIH-458-500UG 500 µg
EUR 569
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

Gab1 (Ab-627) Conjugated Antibody
C21283 100ul
EUR 397

hsa-miR-627 miRNA Inhibitor
MIH03272 2 x 5.0 nmol
EUR 176

hsa-miR-627 miRNA Antagomir
MNH03272 2 x 5.0 nmol
EUR 329

hsa-miR-627-3p Primers
MPH03390 150 ul / 10 uM
EUR 121

hsa-miR-627-5p Primers
MPH03391 150 ul / 10 uM
EUR 121

Zinc Finger Protein 627 (ZNF627) Antibody
20-abx306221
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Zinc Finger Protein 627 (ZNF627) Antibody
abx037044-100ug 100 ug
EUR 391

Anti-STAT4 (aa 613-627) antibody
STJ72162 100 µg
EUR 359

hsa-miR-627-3p miRNA Inhibitor
MIH03273 2 x 5.0 nmol
EUR 176

hsa-miR-627-5p miRNA Inhibitor
MIH03274 2 x 5.0 nmol
EUR 176

hsa-miR-627-3p miRNA Antagomir
MNH03273 2 x 5.0 nmol
EUR 329

hsa-miR-627-5p miRNA Antagomir
MNH03274 2 x 5.0 nmol
EUR 329

Recombinant (E.Coli) purified Mycobacterium Tuberculosis Heat Shock Protein 65 (hsp65/groEL-2/Cpn60-2)
RP-627 10 ug
EUR 286

Poly Ig receptor Recombinant Protein
96-627 0.1 mg
EUR 490.25
Description: Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC). PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

HGF Recombinant Protein
40-627 5 ug
EUR 259.25
Description: HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein containing 697 amino acid residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues. Recombinant Human HGF, sourced from HEK293 cells, is a 79.4 kDa polypeptide consisting of 695 amino acid residues. As a result of glycosylation, Recombinant Human HGF migrates with an apparent molecular mass of approximately 68-85 kDa by SDS-PAGE gel, under non-reducing conditions.

CDK2AP2 Recombinant Protein
91-627 0.05 mg
EUR 311.75
Description: CDK2AP2, also known as DOC1R, is short for cyclin-dependent kinase 2-associated protein 2. The gene CDK2AP2 encodes this protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. It belongs to the CDK2AP family. CDK2AP1 (cyclin-dependent kinase 2-associated protein 1), corresponding to the gene doc-1 (deleted in oral cancer 1), is a tumor suppressor protein. The doc-1 gene is absent or down-regulated in hamster oral cancer cells and in many other cancer cell types. The ubiquitously expressed CDK2AP1 protein is the only known specific inhibitor of CDK2, making it an important component of cell cycle regulation during G(1)-to-S phase transition.

Irisin Recombinant Protein
92-627 0.05 mg
EUR 542.75
Description: Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation.Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor gamma coactivator 1 alpha (PGC1 alpha) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-48T 48T
EUR 317

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-96T 96T
EUR 496

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E11201 96T
EUR 361

Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E20317 96T
EUR 361

Zinc Finger Protein 627 (ZNF627) Antibody (HRP)
20-abx306222
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Zinc Finger Protein 627 (ZNF627) Antibody (FITC)
20-abx306223
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Zinc Finger Protein 627 (ZNF627) Antibody (Biotin)
20-abx306224
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human LRRC32 Protein (His 20-Asn 627) [Fc]
VAng-1903Lsx-100g 100 µg
EUR 1178
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1)

Human LRRC32 Protein (His 20-Asn 627) [Fc]
VAng-1903Lsx-1mg 1 mg
EUR 6924
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1)

Recombinant Treponema Pallidum TP_0179 Protein (aa 1-627)
VAng-Cr1348-inquire inquire Ask for price
Description: Treponema Pallidum (strain Nichols) uncharacterized protein TP_0179 (TP_0179), recombinant protein.

Recombinant Pseudomonas Aeruginosa thiC Protein (aa 1-627)
VAng-Cr0715-inquire inquire Ask for price
Description: Pseudomonas Aeruginosa (strain PA7) phosphomethylpyrimidine synthase (thiC), recombinant protein.

Polyclonal STAT4 (aa 613-627) Antibody (internal region)
APG00648G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human STAT4 (aa 613-627) (internal region). This antibody is tested and proven to work in the following applications:

Recombinant Shigella Flexneri mutL Protein (aa 1-627)
VAng-Lsx07960-inquire inquire Ask for price
Description: Shigella Flexneri serotype 5b DNA mismatch repair protein mutL, recombinant protein.

Recombinant Caenorhabditis Elegans B0280.2 Protein (aa 1-627)
VAng-Ly3032-inquire inquire Ask for price
Description: Caenorhabditis Elegans uncharacterized protein B0280.2 (B0280.2), partial, recombination protein.

Recombinant Caenorhabditis Elegans B0361.3 Protein (aa 1-627)
VAng-Ly3051-inquire inquire Ask for price
Description: Caenorhabditis Elegans uncharacterized protein B0361.3 (B0361.3), partial, recombination protein.

Recombinant Clostridium Phytofermentans mnmG Protein (aa 1-627)
VAng-Lsx01361-inquire inquire Ask for price
Description: Clostridium Phytofermentans tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, recombinant protein.

Recombinant Mycobacterium Smegmatis MSMEG_5130 Protein (aa 28-627)
VAng-Yyj4733-inquire inquire Ask for price
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW (MSMEG_5130), recombinant protein.

Human Zinc finger protein 627, ZNF627 ELISA KIT
ELI-14719h 96 Tests
EUR 824

Human pre-microRNA Expression Construct Lenti-miR-627
PMIRH627PA-1 Bacterial Streak
EUR 684

Factor XI Antibody Pair
55R-FAC11-KT 5 plates
EUR 745
Description: Factor XI antigen Matched Pair antibody Set for ELISA

Factor IX Antibody Pair
55R-FAC9-KT 5 plates
EUR 760
Description: Factor IX antigen Matched Pair antibody Set for ELISA

Fibrinogen Matched Pair antibody Set
55R-FIBRINO-KT set
EUR 833
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory

Mouse RANKL ELISA Kit
55R-MRANKL-KT 1 kit
EUR 658
Description: ELISA kit for detection of Mouse RANKL in the research laboratory

VWF Antibody Pair
55R-VWF-KT 5 plates
EUR 775
Description: VWF antigen Matched Pair antibody Set for ELISA

Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAE ADC
ADC-W-627 1mg Ask for price
Description: This ADC product is comprised of an engineerd anti-ERBB2 antibody (trastuzumab with LLQGG tag at Fc) conjugated via a Aminocaproyl linker to MMAE

Anti-Ms CD80 Purified
11-627-C100 0.1 mg
EUR 113

gp100 (619-627) (AA: Arg-Leu-Met-Lys-Gln-Asp-Phe-Ser-Val) (MW: 1123.35)
SP-88276-5 5 mg
EUR 225