Effects of novel brain-penetrating oxime acetylcholinesterase reactivators on sarin surrogate-induced changes in rat brain gene expression

Effects of novel brain-penetrating oxime acetylcholinesterase reactivators on sarin surrogate-induced changes in rat brain gene expression

Previous assassinations and terrorist assaults reveal the necessity for a simpler antidote in opposition to nerve brokers and different organophosphates (OP) that trigger mind harm by means of inhibition of acetylcholinesterase (AChE). Our lab has invented a platform of phenoxyalkyl pyridinium oximes (US patent 9,277,937) that reveal the flexibility to cross the blood-brain barrier in in vivo rat assessments with a sarin surrogate nitrophenyl isopropyl methylphosphonate (NIMP) and supply proof of mind penetration by decreasing cessation time of seizure-like behaviors, accumulation of glial fibrillary acidic protein (GFAP), and hippocampal neuropathology, versus the at the moment permitted oxime, 2-pyridine aldoxime methyl chloride (2-PAM).

Utilizing two of the novel oximes (Oximes 1 and 20), this challenge examined whether or not gene expression adjustments may assist clarify this safety. Expression adjustments within the piriform cortex had been examined utilizing polymerase chain response arrays for inflammatory cytokines and receptors. The hippocampus was examined by way of quantitative polymerase chain response for the expression of immediate-early genes concerned in mind restore (Bdnf), rising neurotoxicity (Fos), and apoptosis management (Jdp2, Bcl2l1, Bcl2l11). Within the piriform cortex, NIMP considerably stimulated expression for the macrophage inflammatory proteins CCL4, IL-1A, and IL-1B. Oxime 20 by itself elicited essentially the most adjustments.

When it was given therapeutically post-NIMP, the most important change occurred: a 310-fold repression of the inflammatory cytokine, CCL12. Within the hippocampus, NIMP elevated the expression of the neurotoxicity marker Fos and decreased the expression of neuroprotective Bdnf and antiapoptotic Bcl2l1. In contrast with 2-PAM, Oxime 20 stimulated Bcl2l1 expression extra and returned expression nearer to the car management values.

Enhanced Vitamin E content material in an Indica rice cultivar harbouring two transgenes from Arabidopsis thaliana concerned in tocopherol biosynthesis pathway

Micronutrient deficiency ends in malnutrition, which is prevalent everywhere in the world and will result in untimely dying in ladies and youngsters (White and Broadley, 2009). Methods formulated earlier together with supplementation and fortified meals weren’t profitable, owing to socio-economic and technical hurdles (Mayer et al. 2008). The subsequently advanced technique of bio-fortification is a viable biotechnological device to attain desired outcomes with out compromising the agronomical values of crops. Within the current research, Agrobacterium-mediated transformation of Indica rice ASD16 with two genes concerned in tocopherol biosynthesis, viz., TC and HPT had been carried out and the transgenic vegetation had been analyzed for the vitamin E (α- tocopherol) content material.

Conferring the genetic trait to enhance important nutrient accumulation within the edible components of staple meals crops, reminiscent of rice, by means of metabolic engineering is taken into account a quick, sustainable, and cost-effective different to traditional breeding (Maestre et al. 2017). In earlier experiences from our lab, enhanced α-tocopherol ranges within the steady transformants of Nicotiana tabacum (Harish et al. 2013a, b) and in Nicotiana benthamiana adopting a transient expression system utilizing A. thaliana tocopherol cyclase (TC) and homogentisate phytyl transferase (HPT) (Sathish et al. 2018) had been proven.

LINE-1 mediated retrotransposition of protein-coding mRNAs is an energetic course of in trendy people for each germline and somatic genomes. Prior works that surveyed human knowledge principally relied on detecting discordant mappings of paired-end quick reads, or exon junctions contained briefly reads. Furthermore, there have been few genome-wide comparisons between gene retrocopies in nice apes and people. On this research, we launched a extra delicate and correct technique to determine processed pseudogenes.

Our technique makes use of lengthy learn assemblies, and extra importantly, is ready to present full size retrocopy sequences in addition to flanking areas that are missed by short-read based mostly strategies. From 22 human people, we pinpointed 40 processed pseudogenes that aren’t current within the human reference genome GRCh38 and recognized 17 pseudogenes which are in GRCh38 however absent from some enter people. This represents a considerably larger discovery price than earlier experiences (39 pseudogenes not within the reference genome out of 939 people). We additionally offered an outline of lineage particular retrocopies in chimpanzee, gorilla and orangutan genomes.

Effects of novel brain-penetrating oxime acetylcholinesterase reactivators on sarin surrogate-induced changes in rat brain gene expression

Coronary heart illness in ladies: a story evaluate

Heart problems is the worldwide main reason for dying in ladies. Organic variations between the sexes, a results of genetic, epigenetic and intercourse hormone-mediated components, are advanced and incompletely understood. These variations are compounded by socio-cultural components and collectively account for the variation within the prevalence, presentation and pure historical past of heart problems between women and men. Though there may be rising recognition of sex-specific determinants of outcomes, ladies stay under-represented in scientific trials, and sex-disaggregated diagnostic and administration methods will not be at the moment advisable in scientific pointers.

Recombinant Mouse Major urinary proteins 11 and 8 (Mup11)

CSB-EP361419MO 3374 mg Ask for price

Mouse Major urinary proteins 11 and 8, Mup8 ELISA KIT

ELI-37512m 96 Tests
EUR 1038

Mouse Major urinary proteins 11 and 8 (MUP8) ELISA Kit

abx534048-96tests 96 tests
EUR 687.5

Major Urinary Protein 11 (MUP11) Antibody

20-abx109984
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  • 100 ug
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Major Urinary Protein 11 (MUP11) Antibody

20-abx109985
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  • 100 ug
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Major Urinary Protein 11 (MUP11) Antibody

abx109984-100l 100 µl
EUR 162.5

Major Urinary Protein 11 (MUP11) Antibody

abx109985-100l 100 µl
EUR 162.5

Major Urinary Protein 11 (MUP11) Antibody (HRP)

20-abx108482
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  • 100 ug
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Major Urinary Protein 11 (MUP11) Antibody (HRP)

20-abx108483
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  • 100 ug
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  • 20 ug
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Major Urinary Protein 11 (MUP11) Antibody (HRP)

abx108482-100g 100 µg
EUR 362.5

Major Urinary Protein 11 (MUP11) Antibody (HRP)

abx108482-20g 20 µg
EUR 162.5

Major Urinary Protein 11 (MUP11) Antibody (HRP)

abx108482-50g 50 µg
EUR 250

Major Urinary Protein 11 (MUP11) Antibody (HRP)

abx108483-100g 100 µg
EUR 362.5

Major Urinary Protein 11 (MUP11) Antibody (HRP)

abx108483-20g 20 µg
EUR 162.5

Major Urinary Protein 11 (MUP11) Antibody (HRP)

abx108483-50g 50 µg
EUR 250

Major Urinary Protein 11 (MUP11) Antibody (FITC)

20-abx107061
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  • 100 ug
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Major Urinary Protein 11 (MUP11) Antibody (FITC)

20-abx107062
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Major Urinary Protein 11 (MUP11) Antibody (FITC)

abx107061-100g 100 µg
EUR 362.5

Major Urinary Protein 11 (MUP11) Antibody (FITC)

abx107061-20g 20 µg
EUR 162.5

Major Urinary Protein 11 (MUP11) Antibody (FITC)

abx107061-50g 50 µg
EUR 250

Major Urinary Protein 11 (MUP11) Antibody (FITC)

abx107062-100g 100 µg
EUR 362.5

Major Urinary Protein 11 (MUP11) Antibody (FITC)

abx107062-20g 20 µg
EUR 162.5

Major Urinary Protein 11 (MUP11) Antibody (FITC)

abx107062-50g 50 µg
EUR 250

Major Urinary Protein 11 (MUP11) Antibody (Biotin)

20-abx105644
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  • 100 ug
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Major Urinary Protein 11 (MUP11) Antibody (Biotin)

20-abx105645
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Major Urinary Protein 11 (MUP11) Antibody (Biotin)

abx105644-100g 100 µg
EUR 362.5

Major Urinary Protein 11 (MUP11) Antibody (Biotin)

abx105644-20g 20 µg
EUR 162.5

Major Urinary Protein 11 (MUP11) Antibody (Biotin)

abx105644-50g 50 µg
EUR 250

Major Urinary Protein 11 (MUP11) Antibody (Biotin)

abx105645-100g 100 µg
EUR 362.5

Major Urinary Protein 11 (MUP11) Antibody (Biotin)

abx105645-20g 20 µg
EUR 162.5

Major Urinary Protein 11 (MUP11) Antibody (Biotin)

abx105645-50g 50 µg
EUR 250

Recombinant Mouse Major urinary protein 11 (Mup11)

CSB-EP361419MOb0 3375 mg Ask for price

Recombinant Mouse Major urinary protein 11 (Mup11)

RPC26286-100ug 100ug
EUR 705.1

Recombinant Mouse Major urinary protein 11 (Mup11)

RPC26286-1mg 1mg
EUR 3237

Recombinant Mouse Major urinary protein 11 (Mup11)

RPC26286-20ug 20ug
EUR 353.4

Major urinary protein 2 Antibody

20-abx109982
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  • 100 ug
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Major urinary protein 2 Antibody

20-abx109983
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  • 100 ug
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Rabbit Major urinary protein 1 ELISA kit

E04M0281-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Major urinary protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Major urinary protein 1 ELISA kit

E04M0281-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Major urinary protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Major urinary protein 1 ELISA kit

E04M0281-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Major urinary protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Major urinary protein 2 Antibody (HRP)

20-abx108480
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  • 100 ug
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Major urinary protein 2 Antibody (HRP)

20-abx108481
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  • 100 ug
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Major urinary protein 2 Antibody (FITC)

20-abx107059
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  • 100 ug
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Major urinary protein 2 Antibody (FITC)

20-abx107060
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  • 100 ug
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Major Urinary Protein 6 (MUP6) Antibody

20-abx319350
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  • 100 ug
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Major Urinary Protein 2 (MUP2) Antibody

abx109982-100l 100 µl
EUR 162.5

Major Urinary Protein 2 (MUP2) Antibody

abx109983-100l 100 µl
EUR 162.5

Major Urinary Protein 6 (MUP6) Antibody

abx319350-100l 100 µl
EUR 250

Major Urinary Protein 6 (MUP6) Antibody

abx319350-50l 50 µl
EUR 162.5

Major urinary protein 2 Antibody (Biotin)

20-abx105642
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  • 100 ug
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Major urinary protein 2 Antibody (Biotin)

20-abx105643
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  • 100 ug
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Mup11 (untagged) - Mouse major urinary protein 11 (Mup11), (10ug)

MC215481 10 µg Ask for price

Mouse Major urinary protein 2 (Mup2)

1-CSB-YP319316MO
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  • 100ug
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Description: Recombinant Mouse Major urinary protein 2(Mup2) expressed in Yeast

Mouse Major urinary protein 6 (Mup6)

1-CSB-EP360881MO
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  • 100ug
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Description: Recombinant Mouse Major urinary protein 6(Mup6) expressed in E.coli

Mouse Major urinary protein 2 (Mup2)

1-CSB-EP319316MO
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  • 100ug
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Description: Recombinant Mouse Major urinary protein 2(Mup2) expressed in E.coli

Major Urinary Protein 6 (MUP6) Antibody (HRP)

20-abx319258
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  • 100 ug
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Major Urinary Protein 2 (MUP2) Antibody (HRP)

abx108480-100g 100 µg
EUR 362.5

Major Urinary Protein 2 (MUP2) Antibody (HRP)

abx108480-20g 20 µg
EUR 162.5

Major Urinary Protein 2 (MUP2) Antibody (HRP)

abx108480-50g 50 µg
EUR 250

Major Urinary Protein 2 (MUP2) Antibody (HRP)

abx108481-100g 100 µg
EUR 362.5

Major Urinary Protein 2 (MUP2) Antibody (HRP)

abx108481-20g 20 µg
EUR 162.5

Major Urinary Protein 2 (MUP2) Antibody (HRP)

abx108481-50g 50 µg
EUR 250

Major Urinary Protein 6 (MUP6) Antibody (HRP)

abx319258-100l 100 µl
EUR 250

Major Urinary Protein 6 (MUP6) Antibody (HRP)

abx319258-50l 50 µl
EUR 162.5

Mup8 (untagged) - Mouse major urinary protein 8 (Mup8), (10ug)

MC215562 10 µg Ask for price

Major Urinary Protein 6 (MUP6) Antibody (FITC)

20-abx319259
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Major Urinary Protein 2 (MUP2) Antibody (FITC)

abx107059-100g 100 µg
EUR 362.5

Major Urinary Protein 2 (MUP2) Antibody (FITC)

abx107059-20g 20 µg
EUR 162.5

Major Urinary Protein 2 (MUP2) Antibody (FITC)

abx107059-50g 50 µg
EUR 250

Major Urinary Protein 2 (MUP2) Antibody (FITC)

abx107060-100g 100 µg
EUR 362.5

Major Urinary Protein 2 (MUP2) Antibody (FITC)

abx107060-20g 20 µg
EUR 162.5

Major Urinary Protein 2 (MUP2) Antibody (FITC)

abx107060-50g 50 µg
EUR 250

Major Urinary Protein 6 (MUP6) Antibody (FITC)

abx319259-100l 100 µl
EUR 250

Major Urinary Protein 6 (MUP6) Antibody (FITC)

abx319259-50l 50 µl
EUR 162.5

Major Urinary Protein 6 (MUP6) Antibody (Biotin)

20-abx319260
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  • 100 ug
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  • 200 ug
  • 20 ug
  • 50 ug

Major Urinary Protein 2 (MUP2) Antibody (Biotin)

abx105642-100g 100 µg
EUR 362.5

Major Urinary Protein 2 (MUP2) Antibody (Biotin)

abx105642-20g 20 µg
EUR 162.5

Major Urinary Protein 2 (MUP2) Antibody (Biotin)

abx105642-50g 50 µg
EUR 250

Major Urinary Protein 2 (MUP2) Antibody (Biotin)

abx105643-100g 100 µg
EUR 362.5

Major Urinary Protein 2 (MUP2) Antibody (Biotin)

abx105643-20g 20 µg
EUR 162.5

Major Urinary Protein 2 (MUP2) Antibody (Biotin)

abx105643-50g 50 µg
EUR 250

Major Urinary Protein 6 (MUP6) Antibody (Biotin)

abx319260-100l 100 µl
EUR 250

Major Urinary Protein 6 (MUP6) Antibody (Biotin)

abx319260-50l 50 µl
EUR 162.5

Mup11 (GFP-tagged) - Mouse major urinary protein 11 (Mup11), (10ug)

MG213341 10 µg Ask for price

Recombinant Mouse Major urinary protein 11 Protein, His, E.coli-1mg

QP7360-ec-1mg 1mg
EUR 2763.6

Mup11 (Myc-DDK-tagged) - Mouse major urinary protein 11 (Mup11)

MR213341 10 µg Ask for price

Recombinant Mouse Major urinary protein 11 Protein, His, E.coli-10ug

QP7360-ec-10ug 10ug
EUR 326.4

Recombinant Mouse Major urinary protein 11 Protein, His, E.coli-50ug

QP7360-ec-50ug 50ug
EUR 434.4

Recombinant Mouse Major urinary protein 11 Protein, His, Yeast-1mg

QP7360-ye-1mg 1mg
EUR 2763.6

Mup8 (GFP-tagged) - Mouse major urinary protein 8 (Mup8), (10ug)

MG212377 10 µg Ask for price

Recombinant Mouse Major urinary protein 11 Protein, His, E.coli-100ug

QP7360-ec-100ug 100ug
EUR 685.2

Recombinant Mouse Major urinary protein 11 Protein, His, E.coli-200ug

QP7360-ec-200ug 200ug
EUR 1077.6

Recombinant Mouse Major urinary protein 11 Protein, His, E.coli-500ug

QP7360-ec-500ug 500ug
EUR 1816.8

Recombinant Mouse Major urinary protein 11 Protein, His, Yeast-10ug

QP7360-ye-10ug 10ug
EUR 326.4

Recombinant Mouse Major urinary protein 11 Protein, His, Yeast-50ug

QP7360-ye-50ug 50ug
EUR 424.8

Mouse Major urinary protein 1 ELISA kit

E01A23372 96T
EUR 700
Description: ELISA

Mouse Major urinary protein 1 ELISA kit

E03M0281-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Major urinary protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Major urinary protein 1 ELISA kit

E03M0281-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Major urinary protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Major urinary protein 1 ELISA kit

E03M0281-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Major urinary protein 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Major urinary protein 20 ELISA Kit

EK3544 96 tests
EUR 739

Mup8 (Myc-DDK-tagged) - Mouse major urinary protein 8 (Mup8)

MR212377 10 µg Ask for price

Major Urinary Protein 1 Mouse Recombinant

rAP-3940 Inquiry Ask for price

Recombinant Mouse Major urinary protein 11 Protein, His, Yeast-100ug

QP7360-ye-100ug 100ug
EUR 685.2

Recombinant Mouse Major urinary protein 11 Protein, His, Yeast-200ug

QP7360-ye-200ug 200ug
EUR 1077.6

Recombinant Mouse Major urinary protein 11 Protein, His, Yeast-500ug

QP7360-ye-500ug 500ug
EUR 1806

Major urinary protein 20

AP86011 1mg
EUR 2640

Recombinant Mouse Major urinary protein 2 (Mup2)

CSB-YP319316MO 6167 mg Ask for price

Recombinant Mouse Major urinary protein 2(Mup2)

AP70990 1mg
EUR 2826

Recombinant Mouse Major urinary protein 2(Mup2)

AP72886 each Ask for price

Recombinant Mouse Major urinary protein 6(Mup6)

AP73876 1mg
EUR 2826

Recombinant Mouse Major urinary protein 6 (Mup6)

CSB-EP360881MO 3348 mg Ask for price

Recombinant Mouse Major urinary protein 2 (Mup2)

CSB-EP319316MO 2781 mg Ask for price

Recombinant Mouse Major urinary protein 6 (Mup6)

RPC22751-100ug 100ug
EUR 705.1

Recombinant Mouse Major urinary protein 6 (Mup6)

RPC22751-1mg 1mg
EUR 3237

Recombinant Mouse Major urinary protein 6 (Mup6)

RPC22751-20ug 20ug
EUR 353.4

Recombinant Mouse Major urinary protein 2 (Mup2)

RPC25090-100ug 100ug
EUR 702.9

Recombinant Mouse Major urinary protein 2 (Mup2)

RPC25090-20ug 20ug
EUR 353.4

Mouse major urinary protein 1 (MUP1) Elisa kit

EK731923 96 Wells
EUR 0.83

Mouse Major urinary protein 6, Mup6 ELISA KIT

ELI-39462m 96 Tests
EUR 1038

Mouse Major urinary protein 5, Mup5 ELISA KIT

ELI-20630m 96 Tests
EUR 1038

Mouse Major urinary protein 2, Mup2 ELISA KIT

ELI-12942m 96 Tests
EUR 1038

Mouse Major urinary protein 1, Mup1 ELISA KIT

ELI-16618m 96 Tests
EUR 1038

Mouse Major urinary protein 4, Mup4 ELISA KIT

ELI-15975m 96 Tests
EUR 1038

Mouse Major urinary protein 3, Mup3 ELISA KIT

ELI-20011m 96 Tests
EUR 1038

Mouse major urinary protein 1 (MUP1) ELISA kit

CSB-EL027563MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativecompetitive ELISA kit for measuring Mouse major urinary protein 1 (MUP1) in samples from serum, plasma, urne, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse major urinary protein 1 (MUP1) ELISA kit

1-CSB-EL027563MO
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Mouse major urinary protein 1 (MUP1) in samples from serum, plasma, urne, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Major urinary protein 1 (MUP1) ELISA Kit

abx534041-96tests 96 tests
EUR 687.5

Mouse Major Urinary Protein 2 (MUP2) ELISA Kit

abx534043-96tests 96 tests
EUR 687.5

Mouse Major urinary protein 3 (MUP3) ELISA Kit

abx534044-96tests 96 tests
EUR 687.5

Mouse Major urinary protein 4 (MUP4) ELISA Kit

abx534045-96tests 96 tests
EUR 687.5

Mouse Major urinary protein 5 (MUP5) ELISA Kit

abx534046-96tests 96 tests
EUR 687.5

Mouse Major urinary protein 6 (MUP6) ELISA Kit

abx534047-96tests 96 tests
EUR 687.5

Mouse Major Urinary Protein 20 (MUP20) ELISA Kit

abx254983-96tests 96 tests
EUR 886.8

Ladies stay extra prone to expertise delays in prognosis, to be handled much less aggressively and to have worse outcomes. As a consequence, heart problems in ladies stays understudied, underdiagnosed and undertreated. This evaluate will deal with female-specific traits of heart problems and the way these might affect on anaesthetic and peri-operative danger evaluation and care. We spotlight important variations between the sexes within the pure historical past of heart problems, together with these illness entities which are extra frequent in ladies, reminiscent of sudden coronary artery dissection or microvascular dysfunction. Given the quickly rising incidence of maternal heart problems and related problems, particular consideration is given to the chance evaluation and administration of those circumstances throughout being pregnant.