Interleukin 17A (IL-17A) plays critical role in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. TNF receptor associated factor 3 (TRAF3) is a receptor proximal negative regulator of IL-17 signaling. Whether TRAF3 exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of OA is not well understood.
In this study, we found that TRAF3 notably suppressed IL-17-induced NF-κB and MAPK activation and subsequent the production of matrix-degrading enzymes. On the contrary, TRAF3 depletion enhanced IL-17 signaling, along with increased matrix-degrading enzymes production. In vivo, cartilage destruction caused by surgery-induced OA was markedly alleviated both in IL-17A deficient mice (IL17a-/-) and TRAF3 transgenic mice (T3TG).
KT 5823 |
B6673-.25 |
ApexBio |
250 µg |
EUR 361 |
KT 5720 |
B9002-.05 |
ApexBio |
50 µg |
EUR 145 |
KT 5720 |
B9002-.1 |
ApexBio |
100 µg |
EUR 232 |
KT 5720 |
B9002-.25 |
ApexBio |
250 µg |
EUR 483 |
KT 5720 |
B9002-.5 |
ApexBio |
500 µg |
EUR 818 |
KT 5823 |
20-abx076629 |
Abbexa |
|
|
- Shipped within 5-12 working days.
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gp100 (619-627) Peptide |
20-abx266111 |
Abbexa |
-
EUR 411.00
-
EUR 662.00
-
EUR 314.00
|
|
- Shipped within 5-10 working days.
|
Gab1 (Ab-627) Antibody |
21283-100ul |
SAB |
100ul |
EUR 252 |
Gab1 (Ab-627) Antibody |
21283-50ul |
SAB |
50ul |
EUR 187 |
GAB1 (Ab-627) Antibody |
CSB-PA582871- |
Cusabio |
|
EUR 335 |
- Form: liquid
- Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibo
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Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
GAB1 (Ab-627) Antibody |
CSB-PA582871-100ul |
Cusabio |
100ul |
EUR 316 |
- Form: liquid
- Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibo
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Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
hsa-miR-627 Primers |
MPH01927 |
ABM |
150 ul / 10 uM |
EUR 121 |
anti-Gab1 (Ab-627) |
LF-PA20172 |
Abfrontier |
100 ul |
EUR 334 |
Description: Rabbit polyclonal to Gab1 |
Plasminogen Receptor (KT) (PLGRKT) Antibody |
20-abx318476 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
KT 5823 (PKG kinase inhibitor) |
SIH-458-100UG |
Stressmarq |
100 µg |
EUR 205 |
- KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
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Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml). |
KT 5823 (PKG kinase inhibitor) |
SIH-458-500UG |
Stressmarq |
500 µg |
EUR 569 |
- KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
- Show more
|
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml). |
Gab1 (Ab-627) Conjugated Antibody |
C21283 |
SAB |
100ul |
EUR 397 |
hsa-miR-627-3p Primers |
MPH03390 |
ABM |
150 ul / 10 uM |
EUR 121 |
hsa-miR-627-5p Primers |
MPH03391 |
ABM |
150 ul / 10 uM |
EUR 121 |
hsa-miR-627 miRNA Inhibitor |
MIH03272 |
ABM |
2 x 5.0 nmol |
EUR 176 |
hsa-miR-627 miRNA Antagomir |
MNH03272 |
ABM |
2 x 5.0 nmol |
EUR 329 |
Recombinant (E.Coli) purified Mycobacterium Tuberculosis Heat Shock Protein 65 (hsp65/groEL-2/Cpn60-2) |
RP-627 |
Alpha Diagnostics |
10 ug |
EUR 286 |
Zinc Finger Protein 627 (ZNF627) Antibody |
abx037044-100ug |
Abbexa |
100 ug |
EUR 391 |
- Shipped within 5-10 working days.
|
Zinc Finger Protein 627 (ZNF627) Antibody |
20-abx306221 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
hsa-miR-627-3p miRNA Inhibitor |
MIH03273 |
ABM |
2 x 5.0 nmol |
EUR 176 |
hsa-miR-627-5p miRNA Inhibitor |
MIH03274 |
ABM |
2 x 5.0 nmol |
EUR 176 |
hsa-miR-627-3p miRNA Antagomir |
MNH03273 |
ABM |
2 x 5.0 nmol |
EUR 329 |
hsa-miR-627-5p miRNA Antagomir |
MNH03274 |
ABM |
2 x 5.0 nmol |
EUR 329 |
Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt |
GA-E0451RT-48T |
GenAsia Biotech |
48T |
EUR 317 |
Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt |
GA-E0451RT-96T |
GenAsia Biotech |
96T |
EUR 496 |
Zinc Finger Protein 627 (ZNF627) Antibody (HRP) |
20-abx306222 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
Zinc Finger Protein 627 (ZNF627) Antibody (FITC) |
20-abx306223 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
Zinc Finger Protein 627 (ZNF627) Antibody (Biotin) |
20-abx306224 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
- Shipped within 5-10 working days.
|
Polyclonal STAT4 (aa 613-627) Antibody (internal region) |
APG00648G |
Leading Biology |
0.1mg |
EUR 484 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human STAT4 (aa 613-627) (internal region). This antibody is tested and proven to work in the following applications: |
Human Zinc finger protein 627, ZNF627 ELISA KIT |
ELI-14719h |
Lifescience Market |
96 Tests |
EUR 824 |
Human pre-microRNA Expression Construct Lenti-miR-627 |
PMIRH627PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
Human LRRC32 Protein (His 20-Asn 627) [Fc] |
VAng-1903Lsx-100g |
Creative Biolabs |
100 µg |
EUR 1178 |
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1) |
Human LRRC32 Protein (His 20-Asn 627) [Fc] |
VAng-1903Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 6924 |
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1) |
Recombinant Clostridium Phytofermentans mnmG Protein (aa 1-627) |
VAng-Lsx01361-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Clostridium Phytofermentans tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, recombinant protein. |
Recombinant Shigella Flexneri mutL Protein (aa 1-627) |
VAng-Lsx07960-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Shigella Flexneri serotype 5b DNA mismatch repair protein mutL, recombinant protein. |
Recombinant Pseudomonas Aeruginosa thiC Protein (aa 1-627) |
VAng-Cr0715-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Pseudomonas Aeruginosa (strain PA7) phosphomethylpyrimidine synthase (thiC), recombinant protein. |
Recombinant Treponema Pallidum TP_0179 Protein (aa 1-627) |
VAng-Cr1348-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Treponema Pallidum (strain Nichols) uncharacterized protein TP_0179 (TP_0179), recombinant protein. |
Recombinant Caenorhabditis Elegans B0280.2 Protein (aa 1-627) |
VAng-Ly3032-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Caenorhabditis Elegans uncharacterized protein B0280.2 (B0280.2), partial, recombination protein. |
Recombinant Caenorhabditis Elegans B0361.3 Protein (aa 1-627) |
VAng-Ly3051-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Caenorhabditis Elegans uncharacterized protein B0361.3 (B0361.3), partial, recombination protein. |
Recombinant Mycobacterium Smegmatis MSMEG_5130 Protein (aa 28-627) |
VAng-Yyj4733-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW (MSMEG_5130), recombinant protein. |
Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAE ADC |
ADC-W-627 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an engineerd anti-ERBB2 antibody (trastuzumab with LLQGG tag at Fc) conjugated via a Aminocaproyl linker to MMAE |
Anti-Ms CD80 Purified |
11-627-C100 |
ExBio |
0.1 mg |
EUR 113 |
Factor XI Antibody Pair |
55R-FAC11-KT |
Fitzgerald |
5 plates |
EUR 745 |
Description: Factor XI antigen Matched Pair antibody Set for ELISA |
Factor IX Antibody Pair |
55R-FAC9-KT |
Fitzgerald |
5 plates |
EUR 760 |
Description: Factor IX antigen Matched Pair antibody Set for ELISA |
Fibrinogen Matched Pair antibody Set |
55R-FIBRINO-KT |
Fitzgerald |
set |
EUR 833 |
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory |
Mouse RANKL ELISA Kit |
55R-MRANKL-KT |
Fitzgerald |
1 kit |
EUR 658 |
Description: ELISA kit for detection of Mouse RANKL in the research laboratory |
VWF Antibody Pair |
55R-VWF-KT |
Fitzgerald |
5 plates |
EUR 775 |
Description: VWF antigen Matched Pair antibody Set for ELISA |
gp100 (619-627) (AA: Arg-Leu-Met-Lys-Gln-Asp-Phe-Ser-Val) (MW: 1123.35) |
SP-88276-5 |
Alpha Diagnostics |
5 mg |
EUR 225 |
In contrast, silencing TRAF3 through adenoviruses worsened cartilage degradation in experimental OA. Moreover, the destructive effect of IL-17 on cartilage was abolished in T3TG mice in an IL-17 intra-articular (IA) injection animal model.