TRAF3 modulates cartilage degradation through its suppression of interleukin 17 signaling.

Interleukin 17A (IL-17A) plays critical role in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. TNF receptor associated factor 3 (TRAF3) is a receptor proximal negative regulator of IL-17 signaling. Whether TRAF3 exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of OA is not well understood.

In this study, we found that TRAF3 notably suppressed IL-17-induced NF-κB and MAPK activation and subsequent the production of matrix-degrading enzymes. On the contrary, TRAF3 depletion enhanced IL-17 signaling, along with increased matrix-degrading enzymes production. In vivo, cartilage destruction caused by surgery-induced OA was markedly alleviated both in IL-17A deficient mice (IL17a-/-) and TRAF3 transgenic mice (T3TG).

KT 5720

B9002-.5 500 µg
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KT 5823

B6673-.05 50 µg
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KT 5823

B6673-.1 100 µg
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KT 5823

B6673-.25 250 µg
EUR 361

PST- KT

PVT11358 2 ug
EUR 370

gp100 (619–627)

5-01246 4 x 5mg Ask for price

gp100 (619-627) Peptide

20-abx266111
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Gab1 (Ab-627) Antibody

21283-100ul 100ul
EUR 252

Gab1 (Ab-627) Antibody

21283-50ul 50ul
EUR 187

GAB1 (Ab-627) Antibody

CSB-PA582871-
EUR 335
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

GAB1 (Ab-627) Antibody

CSB-PA582871-100ul 100ul
EUR 316
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

anti-Gab1 (Ab-627)

LF-PA20172 100 ul
EUR 334
Description: Rabbit polyclonal to Gab1

hsa-miR-627 Primers

MPH01927 150 ul / 10 uM
EUR 121

Plasminogen Receptor (KT) (PLGRKT) Antibody

20-abx318476
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KT 5823 (PKG kinase inhibitor)

SIH-458-100UG 100 µg
EUR 205
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KT 5823 (PKG kinase inhibitor)

SIH-458-500UG 500 µg
EUR 569
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Gab1 (Ab-627) Conjugated Antibody

C21283 100ul
EUR 397

hsa-miR-627 miRNA Inhibitor

MIH03272 2 x 5.0 nmol
EUR 176

hsa-miR-627 miRNA Antagomir

MNH03272 2 x 5.0 nmol
EUR 329

hsa-miR-627-3p Primers

MPH03390 150 ul / 10 uM
EUR 121

hsa-miR-627-5p Primers

MPH03391 150 ul / 10 uM
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Zinc Finger Protein 627 (ZNF627) Antibody

20-abx306221
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abx037044-100ug 100 ug
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Anti-STAT4 (aa 613-627) antibody

STJ72162 100 µg
EUR 359

hsa-miR-627-3p miRNA Inhibitor

MIH03273 2 x 5.0 nmol
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hsa-miR-627-5p miRNA Inhibitor

MIH03274 2 x 5.0 nmol
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hsa-miR-627-3p miRNA Antagomir

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Recombinant (E.Coli) purified Mycobacterium Tuberculosis Heat Shock Protein 65 (hsp65/groEL-2/Cpn60-2)

RP-627 10 ug
EUR 286

Poly Ig receptor Recombinant Protein

96-627 0.1 mg
EUR 490.25
Description: Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC). PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

HGF Recombinant Protein

40-627 5 ug
EUR 259.25
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CDK2AP2 Recombinant Protein

91-627 0.05 mg
EUR 311.75
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Irisin Recombinant Protein

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EUR 542.75
Description: Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation.Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor gamma coactivator 1 alpha (PGC1 alpha) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.

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Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

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20-abx306222
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EUR 1178
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Recombinant Caenorhabditis Elegans B0280.2 Protein (aa 1-627)

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Recombinant Clostridium Phytofermentans mnmG Protein (aa 1-627)

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Recombinant Mycobacterium Smegmatis MSMEG_5130 Protein (aa 28-627)

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ELI-14719h 96 Tests
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Human pre-microRNA Expression Construct Lenti-miR-627

PMIRH627PA-1 Bacterial Streak
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Factor XI Antibody Pair

55R-FAC11-KT 5 plates
EUR 745
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Factor IX Antibody Pair

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EUR 760
Description: Factor IX antigen Matched Pair antibody Set for ELISA

Fibrinogen Matched Pair antibody Set

55R-FIBRINO-KT set
EUR 833
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory

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55R-MRANKL-KT 1 kit
EUR 658
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VWF Antibody Pair

55R-VWF-KT 5 plates
EUR 775
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Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAE ADC

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Anti-Ms CD80 Purified

11-627-C100 0.1 mg
EUR 113

gp100 (619-627) (AA: Arg-Leu-Met-Lys-Gln-Asp-Phe-Ser-Val) (MW: 1123.35)

SP-88276-5 5 mg
EUR 225

In contrast, silencing TRAF3 through adenoviruses worsened cartilage degradation in experimental OA. Moreover, the destructive effect of IL-17 on cartilage was abolished in T3TG mice in an IL-17 intra-articular (IA) injection animal model.