TRAF3 modulates cartilage degradation through its suppression of interleukin 17 signaling.

Interleukin 17A (IL-17A) plays critical role in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. TNF receptor associated factor 3 (TRAF3) is a receptor proximal negative regulator of IL-17 signaling. Whether TRAF3 exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of OA is not well understood.

In this study, we found that TRAF3 notably suppressed IL-17-induced NF-κB and MAPK activation and subsequent the production of matrix-degrading enzymes. On the contrary, TRAF3 depletion enhanced IL-17 signaling, along with increased matrix-degrading enzymes production. In vivo, cartilage destruction caused by surgery-induced OA was markedly alleviated both in IL-17A deficient mice (IL17a^-/-) and TRAF3 transgenic mice (T3TG).

KT 5720
B9002-.5	ApexBio	500 µg	EUR 818

KT 5823
B6673-.05	ApexBio	50 µg	EUR 123

KT 5823
B6673-.1	ApexBio	100 µg	EUR 190

KT 5823
B6673-.25	ApexBio	250 µg	EUR 361

PST- KT
PVT11358	Lifescience Market	2 ug	EUR 370

gp100 (619–627)
5-01246	CHI Scientific	4 x 5mg	Ask for price

gp100 (619-627) Peptide
20-abx266111	Abbexa	EUR 411.00 EUR 662.00 EUR 314.00	10 mg 25 mg 5 mg

Gab1 (Ab-627) Antibody
21283-100ul	SAB	100ul	EUR 252

Gab1 (Ab-627) Antibody
21283-50ul	SAB	50ul	EUR 187

GAB1 (Ab-627) Antibody
CSB-PA582871-	Cusabio		EUR 335
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

GAB1 (Ab-627) Antibody
CSB-PA582871-100ul	Cusabio	100ul	EUR 316
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

anti-Gab1 (Ab-627)
LF-PA20172	Abfrontier	100 ul	EUR 334
Description: Rabbit polyclonal to Gab1

hsa-miR-627 Primers
MPH01927	ABM	150 ul / 10 uM	EUR 121

Plasminogen Receptor (KT) (PLGRKT) Antibody
20-abx318476	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

KT 5823 (PKG kinase inhibitor)
SIH-458-100UG	Stressmarq	100 µg	EUR 205
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)
SIH-458-500UG	Stressmarq	500 µg	EUR 569
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

Gab1 (Ab-627) Conjugated Antibody
C21283	SAB	100ul	EUR 397

hsa-miR-627 miRNA Inhibitor
MIH03272	ABM	2 x 5.0 nmol	EUR 176

hsa-miR-627 miRNA Antagomir
MNH03272	ABM	2 x 5.0 nmol	EUR 329

hsa-miR-627-3p Primers
MPH03390	ABM	150 ul / 10 uM	EUR 121

hsa-miR-627-5p Primers
MPH03391	ABM	150 ul / 10 uM	EUR 121

Zinc Finger Protein 627 (ZNF627) Antibody
20-abx306221	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Zinc Finger Protein 627 (ZNF627) Antibody
abx037044-100ug	Abbexa	100 ug	EUR 391

Anti-STAT4 (aa 613-627) antibody
STJ72162	St John's Laboratory	100 µg	EUR 359

hsa-miR-627-3p miRNA Inhibitor
MIH03273	ABM	2 x 5.0 nmol	EUR 176

hsa-miR-627-5p miRNA Inhibitor
MIH03274	ABM	2 x 5.0 nmol	EUR 176

hsa-miR-627-3p miRNA Antagomir
MNH03273	ABM	2 x 5.0 nmol	EUR 329

hsa-miR-627-5p miRNA Antagomir
MNH03274	ABM	2 x 5.0 nmol	EUR 329

Recombinant (E.Coli) purified Mycobacterium Tuberculosis Heat Shock Protein 65 (hsp65/groEL-2/Cpn60-2)
RP-627	Alpha Diagnostics	10 ug	EUR 286

Poly Ig receptor Recombinant Protein
96-627	ProSci	0.1 mg	EUR 490.25
Description: Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC). PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

HGF Recombinant Protein
40-627	ProSci	5 ug	EUR 259.25
Description: HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein containing 697 amino acid residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues. Recombinant Human HGF, sourced from HEK293 cells, is a 79.4 kDa polypeptide consisting of 695 amino acid residues. As a result of glycosylation, Recombinant Human HGF migrates with an apparent molecular mass of approximately 68-85 kDa by SDS-PAGE gel, under non-reducing conditions.

CDK2AP2 Recombinant Protein
91-627	ProSci	0.05 mg	EUR 311.75
Description: CDK2AP2, also known as DOC1R, is short for cyclin-dependent kinase 2-associated protein 2. The gene CDK2AP2 encodes this protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. It belongs to the CDK2AP family. CDK2AP1 (cyclin-dependent kinase 2-associated protein 1), corresponding to the gene doc-1 (deleted in oral cancer 1), is a tumor suppressor protein. The doc-1 gene is absent or down-regulated in hamster oral cancer cells and in many other cancer cell types. The ubiquitously expressed CDK2AP1 protein is the only known specific inhibitor of CDK2, making it an important component of cell cycle regulation during G(1)-to-S phase transition.

Irisin Recombinant Protein
92-627	ProSci	0.05 mg	EUR 542.75
Description: Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation.Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor gamma coactivator 1 alpha (PGC1 alpha) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-48T	GenAsia Biotech	48T	EUR 317

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-96T	GenAsia Biotech	96T	EUR 496

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E11201	Qayee Biotechnology	96T	EUR 361

Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E20317	Qayee Biotechnology	96T	EUR 361

Zinc Finger Protein 627 (ZNF627) Antibody (HRP)
20-abx306222	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Zinc Finger Protein 627 (ZNF627) Antibody (FITC)
20-abx306223	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Zinc Finger Protein 627 (ZNF627) Antibody (Biotin)
20-abx306224	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Human LRRC32 Protein (His 20-Asn 627) [Fc]
VAng-1903Lsx-100g	Creative Biolabs	100 µg	EUR 1178
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1)

Human LRRC32 Protein (His 20-Asn 627) [Fc]
VAng-1903Lsx-1mg	Creative Biolabs	1 mg	EUR 6924
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1)

Recombinant Treponema Pallidum TP_0179 Protein (aa 1-627)
VAng-Cr1348-inquire	Creative Biolabs	inquire	Ask for price
Description: Treponema Pallidum (strain Nichols) uncharacterized protein TP_0179 (TP_0179), recombinant protein.

Recombinant Pseudomonas Aeruginosa thiC Protein (aa 1-627)
VAng-Cr0715-inquire	Creative Biolabs	inquire	Ask for price
Description: Pseudomonas Aeruginosa (strain PA7) phosphomethylpyrimidine synthase (thiC), recombinant protein.

Polyclonal STAT4 (aa 613-627) Antibody (internal region)
APG00648G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human STAT4 (aa 613-627) (internal region). This antibody is tested and proven to work in the following applications:

Recombinant Shigella Flexneri mutL Protein (aa 1-627)
VAng-Lsx07960-inquire	Creative Biolabs	inquire	Ask for price
Description: Shigella Flexneri serotype 5b DNA mismatch repair protein mutL, recombinant protein.

Recombinant Caenorhabditis Elegans B0280.2 Protein (aa 1-627)
VAng-Ly3032-inquire	Creative Biolabs	inquire	Ask for price
Description: Caenorhabditis Elegans uncharacterized protein B0280.2 (B0280.2), partial, recombination protein.

Recombinant Caenorhabditis Elegans B0361.3 Protein (aa 1-627)
VAng-Ly3051-inquire	Creative Biolabs	inquire	Ask for price
Description: Caenorhabditis Elegans uncharacterized protein B0361.3 (B0361.3), partial, recombination protein.

Recombinant Clostridium Phytofermentans mnmG Protein (aa 1-627)
VAng-Lsx01361-inquire	Creative Biolabs	inquire	Ask for price
Description: Clostridium Phytofermentans tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, recombinant protein.

Recombinant Mycobacterium Smegmatis MSMEG_5130 Protein (aa 28-627)
VAng-Yyj4733-inquire	Creative Biolabs	inquire	Ask for price
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW (MSMEG_5130), recombinant protein.

Human Zinc finger protein 627, ZNF627 ELISA KIT
ELI-14719h	Lifescience Market	96 Tests	EUR 824

Human pre-microRNA Expression Construct Lenti-miR-627
PMIRH627PA-1	SBI	Bacterial Streak	EUR 684

Factor XI Antibody Pair
55R-FAC11-KT	Fitzgerald	5 plates	EUR 745
Description: Factor XI antigen Matched Pair antibody Set for ELISA

Factor IX Antibody Pair
55R-FAC9-KT	Fitzgerald	5 plates	EUR 760
Description: Factor IX antigen Matched Pair antibody Set for ELISA

Fibrinogen Matched Pair antibody Set
55R-FIBRINO-KT	Fitzgerald	set	EUR 833
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory

Mouse RANKL ELISA Kit
55R-MRANKL-KT	Fitzgerald	1 kit	EUR 658
Description: ELISA kit for detection of Mouse RANKL in the research laboratory

VWF Antibody Pair
55R-VWF-KT	Fitzgerald	5 plates	EUR 775
Description: VWF antigen Matched Pair antibody Set for ELISA

Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAE ADC
ADC-W-627	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an engineerd anti-ERBB2 antibody (trastuzumab with LLQGG tag at Fc) conjugated via a Aminocaproyl linker to MMAE

Anti-Ms CD80 Purified
11-627-C100	ExBio	0.1 mg	EUR 113

gp100 (619-627) (AA: Arg-Leu-Met-Lys-Gln-Asp-Phe-Ser-Val) (MW: 1123.35)
SP-88276-5	Alpha Diagnostics	5 mg	EUR 225

In contrast, silencing TRAF3 through adenoviruses worsened cartilage degradation in experimental OA. Moreover, the destructive effect of IL-17 on cartilage was abolished in T3TG mice in an IL-17 intra-articular (IA) injection animal model.