TRAF3 modulates cartilage degradation through its suppression of interleukin 17 signaling.

Interleukin 17A (IL-17A) plays critical role in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. TNF receptor associated factor 3 (TRAF3) is a receptor proximal negative regulator of IL-17 signaling. Whether TRAF3 exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of OA is not well understood.

In this study, we found that TRAF3 notably suppressed IL-17-induced NF-κB and MAPK activation and subsequent the production of matrix-degrading enzymes. On the contrary, TRAF3 depletion enhanced IL-17 signaling, along with increased matrix-degrading enzymes production. In vivo, cartilage destruction caused by surgery-induced OA was markedly alleviated both in IL-17A deficient mice (IL17a^-/-) and TRAF3 transgenic mice (T3TG).

KT 5823
B6673-.1	ApexBio	100 µg	EUR 190

KT 5823
B6673-.25	ApexBio	250 µg	EUR 361

KT 5720
B9002-.05	ApexBio	50 µg	EUR 145

KT 5720
B9002-.1	ApexBio	100 µg	EUR 232

KT 5720
B9002-.25	ApexBio	250 µg	EUR 483

KT 5720
B9002-.5	ApexBio	500 µg	EUR 818

PST- KT
PVT11358	Lifescience Market	2 ug	EUR 370

gp100 (619–627)
5-01246	CHI Scientific	4 x 5mg	Ask for price

Gab1 (Ab-627) Antibody
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Gab1 (Ab-627) Antibody
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GAB1 (Ab-627) Antibody
CSB-PA582871-	Cusabio		EUR 335
Form: liquid Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibo Show more
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

GAB1 (Ab-627) Antibody
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Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

gp100 (619-627) Peptide
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Plasminogen Receptor (KT) (PLGRKT) Antibody
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KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen Show more
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KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen Show more
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

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GA-E0451RT-48T	GenAsia Biotech	48T	EUR 317

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11-627-C100	ExBio	0.1 mg	EUR 113

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In contrast, silencing TRAF3 through adenoviruses worsened cartilage degradation in experimental OA. Moreover, the destructive effect of IL-17 on cartilage was abolished in T3TG mice in an IL-17 intra-articular (IA) injection animal model.