Interleukin 17A (IL-17A) plays critical role in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. TNF receptor associated factor 3 (TRAF3) is a receptor proximal negative regulator of IL-17 signaling. Whether TRAF3 exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of OA is not well understood.
In this study, we found that TRAF3 notably suppressed IL-17-induced NF-κB and MAPK activation and subsequent the production of matrix-degrading enzymes. On the contrary, TRAF3 depletion enhanced IL-17 signaling, along with increased matrix-degrading enzymes production. In vivo, cartilage destruction caused by surgery-induced OA was markedly alleviated both in IL-17A deficient mice (IL17a-/-) and TRAF3 transgenic mice (T3TG).
KT 5720 |
B9002-.5 |
ApexBio |
500 µg |
EUR 981.6 |
KT 5823 |
B6673-.05 |
ApexBio |
50 µg |
EUR 147.6 |
KT 5823 |
B6673-.1 |
ApexBio |
100 µg |
EUR 228 |
KT 5823 |
B6673-.25 |
ApexBio |
250 µg |
EUR 433.2 |
KT-362 fumarate |
T27753-10mg |
TargetMol Chemicals |
10mg |
Ask for price |
|
Description: KT-362 fumarate |
KT-362 fumarate |
T27753-50mg |
TargetMol Chemicals |
50mg |
Ask for price |
|
Description: KT-362 fumarate |
Gp100 (619-627) |
TP1574-10mg |
TargetMol Chemicals |
10mg |
Ask for price |
|
Description: Gp100 (619-627) |
Gp100 (619-627) |
TP1574-50mg |
TargetMol Chemicals |
50mg |
Ask for price |
|
Description: Gp100 (619-627) |
Forchlorfenuron (KT-30, CPPU) |
C7187-1000 |
ApexBio |
1g |
EUR 85 |
|
Forchlorfenuron (KT-30, CPPU) |
C7187-500 |
ApexBio |
500mg |
EUR 50 |
|
gp100 (619-627) Peptide |
20-abx266111 |
Abbexa |
-
EUR 493.20
-
EUR 794.40
-
EUR 376.80
|
|
|
Gab1 (Ab-627) Antibody |
21283-100ul |
SAB |
100ul |
EUR 302.4 |
Gab1 (Ab-627) Antibody |
21283-50ul |
SAB |
50ul |
EUR 224.4 |
GAB1 (Ab-627) Antibody |
CSB-PA582871- |
Cusabio |
each |
EUR 402 |
|
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
GAB1 (Ab-627) Antibody |
CSB-PA582871-100ul |
Cusabio |
100ul |
EUR 379.2 |
|
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
hsa-miR-627 Primers |
MPH01927 |
ABM |
150 ul / 10 uM |
EUR 145.2 |
anti-Gab1 (Ab-627) |
LF-PA20172 |
Abfrontier |
100 ul |
EUR 400.8 |
Description: Rabbit polyclonal to Gab1 |
Gab1 (Ab-627) Antibody |
E021283-1 |
EnoGene |
50μg/50μl |
EUR 100 |
Description: Available in various conjugation types. |
Gab1 (Ab-627) Antibody |
E021283-2 |
EnoGene |
100μg/100μl |
EUR 170 |
Description: Available in various conjugation types. |
Gab1 (Ab-627) Antibody |
E11-7090B |
EnoGene |
100μg/100μl |
EUR 225 |
Description: Available in various conjugation types. |
GAB1 (Ab-627) Antibody |
8B7090 |
AAT Bioquest |
50ug |
EUR 368 |
Description: GAB1 (Ab-627) Antibody |
Gab1 (Ab-627) Antibody |
21283 |
SAB |
100ul |
EUR 319 |
Plasminogen Receptor (KT) (PLGRKT) Antibody |
20-abx318476 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
KT 5823 (PKG kinase inhibitor) |
SIH-458-100UG |
Stressmarq |
100 µg |
EUR 246 |
|
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml). |
KT 5823 (PKG kinase inhibitor) |
SIH-458-500UG |
Stressmarq |
500 µg |
EUR 682.8 |
|
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml). |
Gab1 (Ab-627) Conjugated Antibody |
C21283 |
SAB |
100ul |
EUR 476.4 |
hsa-miR-627 miRNA Antagomir |
MNH03272 |
ABM |
2 x 5.0 nmol |
EUR 394.8 |
hsa-miR-627 miRNA Inhibitor |
MIH03272 |
ABM |
2 x 5.0 nmol |
EUR 211.2 |
hsa-miR-627-3p Primers |
MPH03390 |
ABM |
150 ul / 10 uM |
EUR 145.2 |
hsa-miR-627-5p Primers |
MPH03391 |
ABM |
150 ul / 10 uM |
EUR 145.2 |
Gab1 (Ab-627) Rabbit pAb |
E2310130 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Anti-Gab1 (Ab-627) Antibody |
Y021283 |
ABM |
100 µg |
EUR 285 |
Zinc Finger Protein 627 (ZNF627) Antibody |
abx037044-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
Zinc Finger Protein 627 (ZNF627) Antibody |
20-abx306221 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
hsa-miR-627-3p miRNA Antagomir |
MNH03273 |
ABM |
2 x 5.0 nmol |
EUR 394.8 |
hsa-miR-627-5p miRNA Antagomir |
MNH03274 |
ABM |
2 x 5.0 nmol |
EUR 394.8 |
hsa-miR-627-3p miRNA Inhibitor |
MIH03273 |
ABM |
2 x 5.0 nmol |
EUR 211.2 |
hsa-miR-627-5p miRNA Inhibitor |
MIH03274 |
ABM |
2 x 5.0 nmol |
EUR 211.2 |
11-KT( 11-keto Testosterone) ELISA Kit |
ELK8908-48T |
ELK Biotech |
48T |
Ask for price |
|
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with 11-KT protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to 11-KT. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of 11-KT in the samples is then determined by comparing the OD of the samples to the standard curve. |
11-KT( 11-keto Testosterone) ELISA Kit |
ELK8908-96T |
ELK Biotech |
96T |
Ask for price |
|
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with 11-KT protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to 11-KT. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of 11-KT in the samples is then determined by comparing the OD of the samples to the standard curve. |
Human11-keto Testosterone (11-KT) ELISA Kit |
NSL2276Hu |
Sunlong |
96 wells |
EUR 468 |
|
Fish 11-keto Testosterone (KT) ELISA Kit |
AE58425FI-48Tests |
Abebio |
48 Tests |
EUR 290 |
|
Description: Fish |
Fish 11-keto Testosterone (KT) ELISA Kit |
AE58425FI-96Tests |
Abebio |
96 Tests |
EUR 540 |
|
Description: Fish |
Human 11-Ketotestosterone, 11-KT GENLISA ELISA |
KBH5106 |
Krishgen |
1 x 96 wells |
EUR 286 |
Fish 11-keto Testosterone (KT) ELISA Kit |
EK11227 |
SAB |
96Т |
EUR 799 |
|
Zinc Finger Protein 627 (ZNF627) Antibody (HRP) |
20-abx306222 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Zinc Finger Protein 627 (ZNF627) Antibody (FITC) |
20-abx306223 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Zinc Finger Protein 627 (ZNF627) Antibody (Biotin) |
20-abx306224 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
hsa-miR-627-5p miRNA Agomir/Antagomir |
AM1423 |
AcceGen |
2 OD, 4 OD, 50 OD (size by request, 1 OD corresponds to 33 ug) |
Ask for price |
Description: MicroRNA: hsa-miR-627-5pAccession Number: MIMAT0003296Mature Sequence: GUGAGUCUCUAAGAAAAGAGGAhsa-miR-627-5p are small non-coding RNAs of 20-22 nucleotides, typically excised from 60-110 nucleotide foldback RNA precursor structures. miRNAs are involved in crucial biological processes, including development, differentiation, apoptosis, and proliferation, through imperfect pairing with target messenger RNAs (mRNAs) of protein-coding genes and the transcriptional or post-transcriptional regulation of their expression. Click here to browse detailed information about hsa-miR-627-5p in miRBase.What is MicroRNA Agomir/Antagomir?MicroRNA Agomir is a special-labeled and chemically modified double-stranded small RNA that mimics the endogenous miRNA to regulate the biological function of the target gene. MicroRNA Antagomir is an especially chemically modified miRNA antagonist. It strongly competes with mature miRNAs in the body to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.Why choose hsa-miR-627-5p miRNA Agomir/Antagomir from Gentaur has extended experience in MicroRNA Agomir/Antagomir synthesis services that cover all human, mouse, and rat miRNAs in the current miRBase. Compared to standard miRNA mimics and inhibitors, Gentaur miRNA agomir and antagomir are more resistant to degradation, thus having a lasting effect: minimum for 1 week, up to 5-6 weeks. These products can be used in in vitro or in vivo miRNA functional studies. |
hsa-miR-627-3p miRNA Agomir/Antagomir |
AM1449 |
AcceGen |
2 OD, 4 OD, 50 OD (size by request, 1 OD corresponds to 33 ug) |
Ask for price |
Description: MicroRNA: hsa-miR-627-3pAccession Number: MIMAT0026623Mature Sequence: UCUUUUCUUUGAGACUCACUhsa-miR-627-3p are small non-coding RNAs of 20-22 nucleotides, typically excised from 60-110 nucleotide foldback RNA precursor structures. miRNAs are involved in crucial biological processes, including development, differentiation, apoptosis, and proliferation, through imperfect pairing with target messenger RNAs (mRNAs) of protein-coding genes and the transcriptional or post-transcriptional regulation of their expression. Click here to browse detailed information about hsa-miR-627-3p in miRBase.What is MicroRNA Agomir/Antagomir?MicroRNA Agomir is a special-labeled and chemically modified double-stranded small RNA that mimics the endogenous miRNA to regulate the biological function of the target gene. MicroRNA Antagomir is an especially chemically modified miRNA antagonist. It strongly competes with mature miRNAs in the body to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.Why choose hsa-miR-627-3p miRNA Agomir/Antagomir from Gentaur has extended experience in MicroRNA Agomir/Antagomir synthesis services that cover all human, mouse, and rat miRNAs in the current miRBase. Compared to standard miRNA mimics and inhibitors, Gentaur miRNA agomir and antagomir are more resistant to degradation, thus having a lasting effect: minimum for 1 week, up to 5-6 weeks. These products can be used in in vitro or in vivo miRNA functional studies. |
Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt |
GA-E0451RT-48T |
GenAsia Biotech |
48T |
EUR 380.4 |
Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt |
GA-E0451RT-96T |
GenAsia Biotech |
96T |
EUR 595.2 |
Canine 11-keto Testosterone(11-KT) ELISA Kit |
NSL1625Ca |
Sunlong |
1720 wells |
EUR 528 |
|
Fish 11-keto Testosterone (11-KT) ELISA Kit |
NSL0002Fi |
Sunlong |
96 wells |
EUR 528 |
|
Bovine 11-keto Testosterone(11-KT) ELISA Kit |
NSL1911Bo |
Sunlong |
96 T |
EUR 528 |
|
Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt |
QY-E20317 |
Qayee Biotechnology |
96T |
EUR 433.2 |
Rat Chondroitin Sulfate Epitope 3B3, CS3B3 ELISA Kt |
KLR0443 |
Krishgen |
1 x 96 wells |
EUR 341 |
Rat Chondroitin Sulfate Epitope 3B3,CS3B3 ELISA Kt |
YLA0979RA-48T |
Shanghai YL Biotech |
48T |
EUR 465 |
Rat Chondroitin Sulfate Epitope 3B3,CS3B3 ELISA Kt |
YLA0979RA-96T |
Shanghai YL Biotech |
96T |
EUR 600 |
Polyclonal STAT4 (aa 613-627) Antibody (internal region) |
APG00648G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human STAT4 (aa 613-627) (internal region). This antibody is tested and proven to work in the following applications: |
Human pre-microRNA Expression Construct Lenti-miR-627 |
PMIRH627PA-1 |
SBI |
Bacterial Streak |
EUR 620 |
Human Zinc finger protein 627, ZNF627 ELISA KIT |
ELI-14719h |
Lifescience Market |
96 Tests |
EUR 988.8 |
Recombinant Caenorhabditis Elegans B0280.2 Protein (aa 1-627) |
VAng-Ly3032-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Caenorhabditis Elegans uncharacterized protein B0280.2 (B0280.2), partial, recombination protein. |
Recombinant Caenorhabditis Elegans B0361.3 Protein (aa 1-627) |
VAng-Ly3051-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Caenorhabditis Elegans uncharacterized protein B0361.3 (B0361.3), partial, recombination protein. |
Recombinant Mycobacterium Smegmatis MSMEG_5130 Protein (aa 28-627) |
VAng-Yyj4733-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW (MSMEG_5130), recombinant protein. |
Recombinant Shigella Flexneri mutL Protein (aa 1-627) |
VAng-Lsx07960-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Shigella Flexneri serotype 5b DNA mismatch repair protein mutL, recombinant protein. |
Recombinant Clostridium Phytofermentans mnmG Protein (aa 1-627) |
VAng-Lsx01361-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Clostridium Phytofermentans tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, recombinant protein. |
Human LRRC32 Protein (His 20-Asn 627) [Fc] |
VAng-1903Lsx-100g |
Creative Biolabs |
100 µg |
EUR 1413.6 |
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1) |
Human LRRC32 Protein (His 20-Asn 627) [Fc] |
VAng-1903Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 8308.8 |
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1) |
Recombinant Pseudomonas Aeruginosa thiC Protein (aa 1-627) |
VAng-Cr0715-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Pseudomonas Aeruginosa (strain PA7) phosphomethylpyrimidine synthase (thiC), recombinant protein. |
Recombinant Treponema Pallidum TP_0179 Protein (aa 1-627) |
VAng-Cr1348-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Treponema Pallidum (strain Nichols) uncharacterized protein TP_0179 (TP_0179), recombinant protein. |
Immortalized Human Bronchial Epithelial Cells (HBEC3-KT) - Cdk4/hTERT |
T0753 |
ABM |
1x10^6 cells / 1.0 ml |
EUR 490 |
Telomerase reverse transcriptase (TERT) (627-656) rabbit polyclonal antibody, Purified |
AP33476PU-N |
Origene Technologies GmbH |
200 µl |
Ask for price |
ZNF627 (untagged) - Human zinc finger protein 627 (ZNF627), transcript variant 2 |
SC336068 |
Origene Technologies GmbH |
10 µg |
Ask for price |
ZNF627 (untagged) - Human zinc finger protein 627 (ZNF627), transcript variant 3 |
SC335547 |
Origene Technologies GmbH |
10 µg |
Ask for price |
ZNF627 (untagged) - Human zinc finger protein 627 (ZNF627), transcript variant 4 |
SC335548 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Recombinant Human TAK1-binding protein 2/TAB-2(627-693) (NZF) protein |
RP10031LQ |
Abclonal |
100μg |
EUR 273 |
|
Recombinant Human TAK1-binding protein 2/TAB-2(627-693) (NZF) protein |
RP10118LQ |
Abclonal |
100μg |
EUR 273 |
|
Lenti-ORF clone of ZNF627 (mGFP-tagged)-Human zinc finger protein 627 (ZNF627) |
RC209636L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
3`UTR clone of zinc finger protein 627 (ZNF627) for miRNA target validation |
SC213599 |
Origene Technologies GmbH |
10 µg |
Ask for price |
ZNF627 (myc-DDK-tagged) - Human zinc finger protein 627 (ZNF627), transcript variant 2 |
RC238174 |
Origene Technologies GmbH |
10 µg |
Ask for price |
ZNF627 (myc-DDK-tagged) - Human zinc finger protein 627 (ZNF627), transcript variant 3 |
RC237653 |
Origene Technologies GmbH |
10 µg |
Ask for price |
ZNF627 (myc-DDK-tagged) - Human zinc finger protein 627 (ZNF627), transcript variant 4 |
RC237654 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti-ORF clone of ZNF627 (Myc-DDK-tagged)-Human zinc finger protein 627 (ZNF627) |
RC209636L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
gp100 (619-627) (AA: Arg-Leu-Met-Lys-Gln-Asp-Phe-Ser-Val) (MW: 1123.35) |
SP-88276-5 |
Alpha Diagnostics |
5 mg |
EUR 270 |
Lenti ORF particles, ZNF627 (mGFP-tagged)-Human zinc finger protein 627 (ZNF627), 200ul, >10^7 TU/mL |
RC209636L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, ZNF627 (Myc-DDK-tagged)-Human zinc finger protein 627 (ZNF627), 200ul, >10^7 TU/mL |
RC209636L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
D10^627 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml. |
TL507072V |
Origene Technologies GmbH |
500 ul each |
Ask for price |
In contrast, silencing TRAF3 through adenoviruses worsened cartilage degradation in experimental OA. Moreover, the destructive effect of IL-17 on cartilage was abolished in T3TG mice in an IL-17 intra-articular (IA) injection animal model.