TRAF3 modulates cartilage degradation through its suppression of interleukin 17 signaling.

Interleukin 17A (IL-17A) plays critical role in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. TNF receptor associated factor 3 (TRAF3) is a receptor proximal negative regulator of IL-17 signaling. Whether TRAF3 exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of OA is not well understood.

In this study, we found that TRAF3 notably suppressed IL-17-induced NF-κB and MAPK activation and subsequent the production of matrix-degrading enzymes. On the contrary, TRAF3 depletion enhanced IL-17 signaling, along with increased matrix-degrading enzymes production. In vivo, cartilage destruction caused by surgery-induced OA was markedly alleviated both in IL-17A deficient mice (IL17a^-/-) and TRAF3 transgenic mice (T3TG).

KT 5823
B6673-.1	ApexBio	100 µg	EUR 190

KT 5823
B6673-.25	ApexBio	250 µg	EUR 361

KT 5720
B9002-.05	ApexBio	50 µg	EUR 145

KT 5720
B9002-.1	ApexBio	100 µg	EUR 232

KT 5720
B9002-.25	ApexBio	250 µg	EUR 483

KT 5720
B9002-.5	ApexBio	500 µg	EUR 818

PST- KT
PVT11358	Lifescience Market	2 ug	EUR 370

gp100 (619–627)
5-01246	CHI Scientific	4 x 5mg	Ask for price

Gab1 (Ab-627) Antibody
21283-100ul	SAB	100ul	EUR 252

Gab1 (Ab-627) Antibody
21283-50ul	SAB	50ul	EUR 187

GAB1 (Ab-627) Antibody
CSB-PA582871-	Cusabio		EUR 335
Form: liquid Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibo Show more
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

GAB1 (Ab-627) Antibody
CSB-PA582871-100ul	Cusabio	100ul	EUR 316
Form: liquid Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibo Show more
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

gp100 (619-627) Peptide
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anti-Gab1 (Ab-627)
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hsa-miR-627 Primers
MPH01927	ABM	150 ul / 10 uM	EUR 121

Plasminogen Receptor (KT) (PLGRKT) Antibody
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KT 5823 (PKG kinase inhibitor)
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KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen Show more
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)
SIH-458-500UG	Stressmarq	500 µg	EUR 569
KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen Show more
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

Gab1 (Ab-627) Conjugated Antibody
C21283	SAB	100ul	EUR 397

hsa-miR-627 miRNA Inhibitor
MIH03272	ABM	2 x 5.0 nmol	EUR 176

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MNH03272	ABM	2 x 5.0 nmol	EUR 329

hsa-miR-627-3p Primers
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MPH03391	ABM	150 ul / 10 uM	EUR 121

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RP-627	Alpha Diagnostics	10 ug	EUR 286

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Anti-STAT4 (aa 613-627) antibody
STJ72162	St John's Laboratory	100 µg	EUR 359

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
GA-E0451RT-48T	GenAsia Biotech	48T	EUR 317

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
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Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt
QY-E11201	Qayee Biotechnology	96T	EUR 361

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Zinc Finger Protein 627 (ZNF627) Antibody (HRP)
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ELI-14719h	Lifescience Market	96 Tests	EUR 824

Human pre-microRNA Expression Construct Lenti-miR-627
PMIRH627PA-1	SBI	Bacterial Streak	EUR 684
Category: MicroRNA Tools

Human LRRC32 Protein (His 20-Asn 627) [Fc]
VAng-1903Lsx-100g	Creative Biolabs	100 µg	EUR 1178
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11-627-C100	ExBio	0.1 mg	EUR 113

Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAE ADC
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Factor XI Antibody Pair
55R-FAC11-KT	Fitzgerald	5 plates	EUR 745
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55R-FIBRINO-KT	Fitzgerald	set	EUR 833
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Mouse RANKL ELISA Kit
55R-MRANKL-KT	Fitzgerald	1 kit	EUR 658
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55R-VWF-KT	Fitzgerald	5 plates	EUR 775
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gp100 (619-627) (AA: Arg-Leu-Met-Lys-Gln-Asp-Phe-Ser-Val) (MW: 1123.35)
SP-88276-5	Alpha Diagnostics	5 mg	EUR 225

In contrast, silencing TRAF3 through adenoviruses worsened cartilage degradation in experimental OA. Moreover, the destructive effect of IL-17 on cartilage was abolished in T3TG mice in an IL-17 intra-articular (IA) injection animal model.