TRAF3 modulates cartilage degradation through its suppression of interleukin 17 signaling.

Interleukin 17A (IL-17A) plays critical role in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. TNF receptor associated factor 3 (TRAF3) is a receptor proximal negative regulator of IL-17 signaling. Whether TRAF3 exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of OA is not well understood.

In this study, we found that TRAF3 notably suppressed IL-17-induced NF-κB and MAPK activation and subsequent the production of matrix-degrading enzymes. On the contrary, TRAF3 depletion enhanced IL-17 signaling, along with increased matrix-degrading enzymes production. In vivo, cartilage destruction caused by surgery-induced OA was markedly alleviated both in IL-17A deficient mice (IL17a-/-) and TRAF3 transgenic mice (T3TG).

KT 5823

B6673-.25 250 µg
EUR 361

KT 5720

B9002-.05 50 µg
EUR 145

KT 5720

B9002-.1 100 µg
EUR 232

KT 5720

B9002-.25 250 µg
EUR 483

KT 5720

B9002-.5 500 µg
EUR 818

KT 5823

20-abx076629
  • EUR 356.00
  • EUR 829.00
  • 100 ug
  • 500 ug
  • Shipped within 5-12 working days.

PST- KT

PVT11358 2 ug
EUR 370

gp100 (619–627)

5-01246 4 x 5mg Ask for price

gp100 (619-627) Peptide

20-abx266111
  • EUR 411.00
  • EUR 662.00
  • EUR 314.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Gab1 (Ab-627) Antibody

21283-100ul 100ul
EUR 252

Gab1 (Ab-627) Antibody

21283-50ul 50ul
EUR 187

GAB1 (Ab-627) Antibody

CSB-PA582871-
EUR 335
  • Form: liquid
  • Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibo
  • Show more
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

GAB1 (Ab-627) Antibody

CSB-PA582871-100ul 100ul
EUR 316
  • Form: liquid
  • Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibo
  • Show more
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

hsa-miR-627 Primers

MPH01927 150 ul / 10 uM
EUR 121

anti-Gab1 (Ab-627)

LF-PA20172 100 ul
EUR 334
Description: Rabbit polyclonal to Gab1

Plasminogen Receptor (KT) (PLGRKT) Antibody

20-abx318476
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

KT 5823 (PKG kinase inhibitor)

SIH-458-100UG 100 µg
EUR 205
  • KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
  • Show more
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)

SIH-458-500UG 500 µg
EUR 569
  • KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependen
  • Show more
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

Gab1 (Ab-627) Conjugated Antibody

C21283 100ul
EUR 397

hsa-miR-627-3p Primers

MPH03390 150 ul / 10 uM
EUR 121

hsa-miR-627-5p Primers

MPH03391 150 ul / 10 uM
EUR 121

hsa-miR-627 miRNA Inhibitor

MIH03272 2 x 5.0 nmol
EUR 176

hsa-miR-627 miRNA Antagomir

MNH03272 2 x 5.0 nmol
EUR 329

Recombinant (E.Coli) purified Mycobacterium Tuberculosis Heat Shock Protein 65 (hsp65/groEL-2/Cpn60-2)

RP-627 10 ug
EUR 286

Zinc Finger Protein 627 (ZNF627) Antibody

abx037044-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Zinc Finger Protein 627 (ZNF627) Antibody

20-abx306221
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

hsa-miR-627-3p miRNA Inhibitor

MIH03273 2 x 5.0 nmol
EUR 176

hsa-miR-627-5p miRNA Inhibitor

MIH03274 2 x 5.0 nmol
EUR 176

hsa-miR-627-3p miRNA Antagomir

MNH03273 2 x 5.0 nmol
EUR 329

hsa-miR-627-5p miRNA Antagomir

MNH03274 2 x 5.0 nmol
EUR 329

Anti-STAT4 (aa 613-627) antibody

STJ72162 100 µg
EUR 359

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

GA-E0451RT-48T 48T
EUR 317

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

GA-E0451RT-96T 96T
EUR 496

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

QY-E11201 96T
EUR 361

Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

QY-E20317 96T
EUR 361

Zinc Finger Protein 627 (ZNF627) Antibody (HRP)

20-abx306222
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Zinc Finger Protein 627 (ZNF627) Antibody (FITC)

20-abx306223
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Zinc Finger Protein 627 (ZNF627) Antibody (Biotin)

20-abx306224
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Polyclonal STAT4 (aa 613-627) Antibody (internal region)

APG00648G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human STAT4 (aa 613-627) (internal region). This antibody is tested and proven to work in the following applications:

Human Zinc finger protein 627, ZNF627 ELISA KIT

ELI-14719h 96 Tests
EUR 824

Human pre-microRNA Expression Construct Lenti-miR-627

PMIRH627PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Human LRRC32 Protein (His 20-Asn 627) [Fc]

VAng-1903Lsx-100g 100 µg
EUR 1178
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1)

Human LRRC32 Protein (His 20-Asn 627) [Fc]

VAng-1903Lsx-1mg 1 mg
EUR 6924
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1)

Recombinant Clostridium Phytofermentans mnmG Protein (aa 1-627)

VAng-Lsx01361-inquire inquire Ask for price
Description: Clostridium Phytofermentans tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, recombinant protein.

Recombinant Shigella Flexneri mutL Protein (aa 1-627)

VAng-Lsx07960-inquire inquire Ask for price
Description: Shigella Flexneri serotype 5b DNA mismatch repair protein mutL, recombinant protein.

Recombinant Pseudomonas Aeruginosa thiC Protein (aa 1-627)

VAng-Cr0715-inquire inquire Ask for price
Description: Pseudomonas Aeruginosa (strain PA7) phosphomethylpyrimidine synthase (thiC), recombinant protein.

Recombinant Treponema Pallidum TP_0179 Protein (aa 1-627)

VAng-Cr1348-inquire inquire Ask for price
Description: Treponema Pallidum (strain Nichols) uncharacterized protein TP_0179 (TP_0179), recombinant protein.

Recombinant Caenorhabditis Elegans B0280.2 Protein (aa 1-627)

VAng-Ly3032-inquire inquire Ask for price
Description: Caenorhabditis Elegans uncharacterized protein B0280.2 (B0280.2), partial, recombination protein.

Recombinant Caenorhabditis Elegans B0361.3 Protein (aa 1-627)

VAng-Ly3051-inquire inquire Ask for price
Description: Caenorhabditis Elegans uncharacterized protein B0361.3 (B0361.3), partial, recombination protein.

Recombinant Mycobacterium Smegmatis MSMEG_5130 Protein (aa 28-627)

VAng-Yyj4733-inquire inquire Ask for price
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW (MSMEG_5130), recombinant protein.

Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAE ADC

ADC-W-627 1mg Ask for price
Description: This ADC product is comprised of an engineerd anti-ERBB2 antibody (trastuzumab with LLQGG tag at Fc) conjugated via a Aminocaproyl linker to MMAE

Anti-Ms CD80 Purified

11-627-C100 0.1 mg
EUR 113

Factor XI Antibody Pair

55R-FAC11-KT 5 plates
EUR 745
Description: Factor XI antigen Matched Pair antibody Set for ELISA

Factor IX Antibody Pair

55R-FAC9-KT 5 plates
EUR 760
Description: Factor IX antigen Matched Pair antibody Set for ELISA

Fibrinogen Matched Pair antibody Set

55R-FIBRINO-KT set
EUR 833
Description: Fibrinogen Matched Pair antibody Set for detection of Human Fibrinogen in the research laboratory

Mouse RANKL ELISA Kit

55R-MRANKL-KT 1 kit
EUR 658
Description: ELISA kit for detection of Mouse RANKL in the research laboratory

VWF Antibody Pair

55R-VWF-KT 5 plates
EUR 775
Description: VWF antigen Matched Pair antibody Set for ELISA

gp100 (619-627) (AA: Arg-Leu-Met-Lys-Gln-Asp-Phe-Ser-Val) (MW: 1123.35)

SP-88276-5 5 mg
EUR 225

In contrast, silencing TRAF3 through adenoviruses worsened cartilage degradation in experimental OA. Moreover, the destructive effect of IL-17 on cartilage was abolished in T3TG mice in an IL-17 intra-articular (IA) injection animal model.