TRAF3 modulates cartilage degradation through its suppression of interleukin 17 signaling.

Interleukin 17A (IL-17A) plays critical role in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. TNF receptor associated factor 3 (TRAF3) is a receptor proximal negative regulator of IL-17 signaling. Whether TRAF3 exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of OA is not well understood.

In this study, we found that TRAF3 notably suppressed IL-17-induced NF-κB and MAPK activation and subsequent the production of matrix-degrading enzymes. On the contrary, TRAF3 depletion enhanced IL-17 signaling, along with increased matrix-degrading enzymes production. In vivo, cartilage destruction caused by surgery-induced OA was markedly alleviated both in IL-17A deficient mice (IL17a-/-) and TRAF3 transgenic mice (T3TG).

KT 5720

B9002-.5 500 µg
EUR 981.6

KT 5823

B6673-.05 50 µg
EUR 147.6

KT 5823

B6673-.1 100 µg
EUR 228

KT 5823

B6673-.25 250 µg
EUR 433.2

PST- KT

PVT11358 2 ug
EUR 444

KT 182

464890 5.0mg
EUR 265

KT 1

584533 50.0mg
EUR 315

KT 5720

532045 1.0mg
EUR 1650

KT 1

T32426-10mg 10mg Ask for price
Description: KT 1

KT 1

T32426-1g 1g Ask for price
Description: KT 1

KT 1

T32426-1mg 1mg Ask for price
Description: KT 1

KT 1

T32426-50mg 50mg Ask for price
Description: KT 1

KT 1

T32426-5mg 5mg Ask for price
Description: KT 1

KT-362 fumarate

T27753-10mg 10mg Ask for price
Description: KT-362 fumarate

KT-362 fumarate

T27753-1g 1g Ask for price
Description: KT-362 fumarate

KT-362 fumarate

T27753-1mg 1mg Ask for price
Description: KT-362 fumarate

KT-362 fumarate

T27753-50mg 50mg Ask for price
Description: KT-362 fumarate

KT-362 fumarate

T27753-5mg 5mg Ask for price
Description: KT-362 fumarate

gp100 (619–627)

5-01246 4 x 5mg Ask for price

Gp100 (619-627)

TP1574-10mg 10mg Ask for price
Description: Gp100 (619-627)

Gp100 (619-627)

TP1574-1g 1g Ask for price
Description: Gp100 (619-627)

Gp100 (619-627)

TP1574-1mg 1mg Ask for price
Description: Gp100 (619-627)

Gp100 (619-627)

TP1574-50mg 50mg Ask for price
Description: Gp100 (619-627)

Gp100 (619-627)

TP1574-5mg 5mg Ask for price
Description: Gp100 (619-627)

Liquiport NF 100 KT.

PUM2680 EACH
EUR 920.4

Forchlorfenuron (KT-30, CPPU)

C7187-1000 1g
EUR 85

Forchlorfenuron (KT-30, CPPU)

C7187-500 500mg
EUR 50

gp100 (619-627) Peptide

20-abx266111
  • EUR 493.20
  • EUR 794.40
  • EUR 376.80
  • 10 mg
  • 25 mg
  • 5 mg

Gab1 (Ab-627) Antibody

21283-100ul 100ul
EUR 302.4

Gab1 (Ab-627) Antibody

21283-50ul 50ul
EUR 224.4

GAB1 (Ab-627) Antibody

CSB-PA582871- each
EUR 402
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

GAB1 (Ab-627) Antibody

CSB-PA582871-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GAB1 (Ab-627). Recognizes GAB1 (Ab-627) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

hsa-miR-627 Primers

MPH01927 150 ul / 10 uM
EUR 145.2

anti-Gab1 (Ab-627)

LF-PA20172 100 ul
EUR 400.8
Description: Rabbit polyclonal to Gab1

Gab1 (Ab-627) Antibody

E021283-1 50μg/50μl
EUR 100
Description: Available in various conjugation types.

Gab1 (Ab-627) Antibody

E021283-2 100μg/100μl
EUR 170
Description: Available in various conjugation types.

Gab1 (Ab-627) Antibody

E11-7090B 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GAB1 (Ab-627) Antibody

8B7090 50ug
EUR 368
Description: GAB1 (Ab-627) Antibody

Gab1 (Ab-627) Antibody

21283 100ul
EUR 319

Plasminogen Receptor (KT) (PLGRKT) Antibody

20-abx318476
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Liquiport NF 1.100 KT.18RC

PUM2656 EACH
EUR 1038

Liquiport NF 1.300 KT.18RC

PUM2668 EACH
EUR 1314

Liquiport NF 300 KT.18RC

PUM2692 EACH
EUR 1112.4

KNF Liquiport NF 300 KT

PUM2694 EACH
EUR 921.6

KT 5823 (PKG kinase inhibitor)

SIH-458-100UG 100 µg
EUR 246
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

KT 5823 (PKG kinase inhibitor)

SIH-458-500UG 500 µg
EUR 682.8
Description: The substance KT 5823 is a pkg kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml).

Cochranes molecular models 1 KT

Z119679-1KT 1KIT
EUR 30.03

Cochranes molecular models 1 KT

Z184756-1KT 1KIT
EUR 32.9

Gab1 (Ab-627) Conjugated Antibody

C21283 100ul
EUR 476.4

hsa-miR-627 miRNA Antagomir

MNH03272 2 x 5.0 nmol
EUR 394.8

hsa-miR-627 miRNA Inhibitor

MIH03272 2 x 5.0 nmol
EUR 211.2

hsa-miR-627-3p Primers

MPH03390 150 ul / 10 uM
EUR 145.2

hsa-miR-627-5p Primers

MPH03391 150 ul / 10 uM
EUR 145.2

Gab1 (Ab-627) Rabbit pAb

E2310130 100ul
EUR 225
Description: Available in various conjugation types.

Anti-Gab1 (Ab-627) Antibody

Y021283 100 µg
EUR 285

KNF Liquiport NF 1.100 KT.18S

PUM2658 EACH
EUR 848.4

KT 170 capacity 163L Cooled Incubator

INC1074 EACH
EUR 7780.07

Zinc Finger Protein 627 (ZNF627) Antibody

abx037044-100ug 100 ug
EUR 469.2

Zinc Finger Protein 627 (ZNF627) Antibody

20-abx306221
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

hsa-miR-627-3p miRNA Antagomir

MNH03273 2 x 5.0 nmol
EUR 394.8

hsa-miR-627-5p miRNA Antagomir

MNH03274 2 x 5.0 nmol
EUR 394.8

hsa-miR-627-3p miRNA Inhibitor

MIH03273 2 x 5.0 nmol
EUR 211.2

hsa-miR-627-5p miRNA Inhibitor

MIH03274 2 x 5.0 nmol
EUR 211.2

Anti-STAT4 (aa 613-627) antibody

STJ72162 100 µg
EUR 430.8

11-KT( 11-keto Testosterone) ELISA Kit

ELK8908-48T 48T Ask for price
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with 11-KT protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to 11-KT. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of 11-KT in the samples is then determined by comparing the OD of the samples to the standard curve.

11-KT( 11-keto Testosterone) ELISA Kit

ELK8908-96T 96T Ask for price
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with 11-KT protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to 11-KT. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of 11-KT in the samples is then determined by comparing the OD of the samples to the standard curve.

Human11-keto Testosterone (11-KT) ELISA Kit

NSL2276Hu 96 wells
EUR 468

Fish 11-keto Testosterone (KT) ELISA Kit

AE58425FI-48Tests 48 Tests
EUR 290
Description: Fish

Fish 11-keto Testosterone (KT) ELISA Kit

AE58425FI-96Tests 96 Tests
EUR 540
Description: Fish

Human 11-Ketotestosterone, 11-KT GENLISA ELISA

KBH5106 1 x 96 wells
EUR 286

Fish 11-keto Testosterone (KT) ELISA Kit

EK11227 96Т
EUR 799

Zinc Finger Protein 627 (ZNF627) Antibody (HRP)

20-abx306222
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Zinc Finger Protein 627 (ZNF627) Antibody (FITC)

20-abx306223
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Zinc Finger Protein 627 (ZNF627) Antibody (Biotin)

20-abx306224
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

hsa-miR-627-5p miRNA Agomir/Antagomir

AM1423 2 OD, 4 OD, 50 OD (size by request, 1 OD corresponds to 33 ug) Ask for price
Description: MicroRNA: hsa-miR-627-5pAccession Number: MIMAT0003296Mature Sequence: GUGAGUCUCUAAGAAAAGAGGAhsa-miR-627-5p are small non-coding RNAs of 20-22 nucleotides, typically excised from 60-110 nucleotide foldback RNA precursor structures. miRNAs are involved in crucial biological processes, including development, differentiation, apoptosis, and proliferation, through imperfect pairing with target messenger RNAs (mRNAs) of protein-coding genes and the transcriptional or post-transcriptional regulation of their expression. Click here to browse detailed information about hsa-miR-627-5p in miRBase.What is MicroRNA Agomir/Antagomir?MicroRNA Agomir is a special-labeled and chemically modified double-stranded small RNA that mimics the endogenous miRNA to regulate the biological function of the target gene. MicroRNA Antagomir is an especially chemically modified miRNA antagonist. It strongly competes with mature miRNAs in the body to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.Why choose hsa-miR-627-5p miRNA Agomir/Antagomir from Gentaur has extended experience in MicroRNA Agomir/Antagomir synthesis services that cover all human, mouse, and rat miRNAs in the current miRBase. Compared to standard miRNA mimics and inhibitors, Gentaur miRNA agomir and antagomir are more resistant to degradation, thus having a lasting effect: minimum for 1 week, up to 5-6 weeks. These products can be used in in vitro or in vivo miRNA functional studies.

hsa-miR-627-3p miRNA Agomir/Antagomir

AM1449 2 OD, 4 OD, 50 OD (size by request, 1 OD corresponds to 33 ug) Ask for price
Description: MicroRNA: hsa-miR-627-3pAccession Number: MIMAT0026623Mature Sequence: UCUUUUCUUUGAGACUCACUhsa-miR-627-3p are small non-coding RNAs of 20-22 nucleotides, typically excised from 60-110 nucleotide foldback RNA precursor structures. miRNAs are involved in crucial biological processes, including development, differentiation, apoptosis, and proliferation, through imperfect pairing with target messenger RNAs (mRNAs) of protein-coding genes and the transcriptional or post-transcriptional regulation of their expression. Click here to browse detailed information about hsa-miR-627-3p in miRBase.What is MicroRNA Agomir/Antagomir?MicroRNA Agomir is a special-labeled and chemically modified double-stranded small RNA that mimics the endogenous miRNA to regulate the biological function of the target gene. MicroRNA Antagomir is an especially chemically modified miRNA antagonist. It strongly competes with mature miRNAs in the body to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.Why choose hsa-miR-627-3p miRNA Agomir/Antagomir from Gentaur has extended experience in MicroRNA Agomir/Antagomir synthesis services that cover all human, mouse, and rat miRNAs in the current miRBase. Compared to standard miRNA mimics and inhibitors, Gentaur miRNA agomir and antagomir are more resistant to degradation, thus having a lasting effect: minimum for 1 week, up to 5-6 weeks. These products can be used in in vitro or in vivo miRNA functional studies.

Mini Diaphragm Vacuum Pump N 938.50 KT.18

PUM2619 EACH
EUR 1550.4

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

GA-E0451RT-48T 48T
EUR 380.4

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

GA-E0451RT-96T 96T
EUR 595.2

Canine 11-keto Testosterone(11-KT) ELISA Kit

NSL1625Ca 1720 wells
EUR 528

Fish 11-keto Testosterone (11-KT) ELISA Kit

NSL0002Fi 96 wells
EUR 528

Bovine 11-keto Testosterone(11-KT) ELISA Kit

NSL1911Bo 96 T
EUR 528

Rat Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

QY-E11201 96T
EUR 433.2

Mouse Chondroitin Sulfate Epitope 3B3(CS3B3 ELISA Kt

QY-E20317 96T
EUR 433.2

Rat Chondroitin Sulfate Epitope 3B3, CS3B3 ELISA Kt

KLR0443 1 x 96 wells
EUR 341

Rat Chondroitin Sulfate Epitope 3B3,CS3B3 ELISA Kt

YLA0979RA-48T 48T
EUR 465

Rat Chondroitin Sulfate Epitope 3B3,CS3B3 ELISA Kt

YLA0979RA-96T 96T
EUR 600

Polyclonal STAT4 (aa 613-627) Antibody (internal region)

APG00648G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human STAT4 (aa 613-627) (internal region). This antibody is tested and proven to work in the following applications:

Human pre-microRNA Expression Construct Lenti-miR-627

PMIRH627PA-1 Bacterial Streak
EUR 620

Human Zinc finger protein 627, ZNF627 ELISA KIT

ELI-14719h 96 Tests
EUR 988.8

Recombinant Caenorhabditis Elegans B0280.2 Protein (aa 1-627)

VAng-Ly3032-inquire inquire Ask for price
Description: Caenorhabditis Elegans uncharacterized protein B0280.2 (B0280.2), partial, recombination protein.

Recombinant Caenorhabditis Elegans B0361.3 Protein (aa 1-627)

VAng-Ly3051-inquire inquire Ask for price
Description: Caenorhabditis Elegans uncharacterized protein B0361.3 (B0361.3), partial, recombination protein.

Recombinant Mycobacterium Smegmatis MSMEG_5130 Protein (aa 28-627)

VAng-Yyj4733-inquire inquire Ask for price
Description: Mycobacterium Smegmatis (strain ATCC 700084 / mc(2)155) Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW (MSMEG_5130), recombinant protein.

Recombinant Shigella Flexneri mutL Protein (aa 1-627)

VAng-Lsx07960-inquire inquire Ask for price
Description: Shigella Flexneri serotype 5b DNA mismatch repair protein mutL, recombinant protein.

Recombinant Clostridium Phytofermentans mnmG Protein (aa 1-627)

VAng-Lsx01361-inquire inquire Ask for price
Description: Clostridium Phytofermentans tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, recombinant protein.

Human LRRC32 Protein (His 20-Asn 627) [Fc]

VAng-1903Lsx-100g 100 µg
EUR 1413.6
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1)

Human LRRC32 Protein (His 20-Asn 627) [Fc]

VAng-1903Lsx-1mg 1 mg
EUR 8308.8
Description: Human LRRC32 protein, human IgG1 Fc tag, expressed in human 293 cells. (Uniprot ID: Q14392-1)

Recombinant Pseudomonas Aeruginosa thiC Protein (aa 1-627)

VAng-Cr0715-inquire inquire Ask for price
Description: Pseudomonas Aeruginosa (strain PA7) phosphomethylpyrimidine synthase (thiC), recombinant protein.

STAT4 (613-627) goat polyclonal antibody, Aff - Purified

AP21276PU-N 100 µg Ask for price

Recombinant Treponema Pallidum TP_0179 Protein (aa 1-627)

VAng-Cr1348-inquire inquire Ask for price
Description: Treponema Pallidum (strain Nichols) uncharacterized protein TP_0179 (TP_0179), recombinant protein.

ZNF627 (untagged)-Human zinc finger protein 627 (ZNF627)

SC313584 10 µg Ask for price

Immortalized Human Bronchial Epithelial Cells (HBEC3-KT) - Cdk4/hTERT

T0753 1x10^6 cells / 1.0 ml
EUR 490

ZNF627 (GFP-tagged) - Human zinc finger protein 627 (ZNF627)

RG209636 10 µg Ask for price

FEM 1.10 KT.18 RCP2 SIMDOS 10 - Liquid Dosing Pump

PUM2720 EACH
EUR 2173.2

FEM 1.02 KT.18 RCP SIMDOS 02 - Liquid Dosing Pump

PUM2728 EACH
EUR 2186.4

Telomerase reverse transcriptase (TERT) (627-656) rabbit polyclonal antibody, Purified

AP33476PU-N 200 µl Ask for price

ZNF627 (Myc-DDK-tagged)-Human zinc finger protein 627 (ZNF627)

RC209636 10 µg Ask for price

ZNF627 (untagged) - Human zinc finger protein 627 (ZNF627), transcript variant 2

SC336068 10 µg Ask for price

ZNF627 (untagged) - Human zinc finger protein 627 (ZNF627), transcript variant 3

SC335547 10 µg Ask for price

ZNF627 (untagged) - Human zinc finger protein 627 (ZNF627), transcript variant 4

SC335548 10 µg Ask for price

Recombinant Human TAK1-binding protein 2/TAB-2(627-693) (NZF) protein

RP10031LQ 100μg
EUR 273

Recombinant Human TAK1-binding protein 2/TAB-2(627-693) (NZF) protein

RP10118LQ 100μg
EUR 273

Lenti-ORF clone of ZNF627 (mGFP-tagged)-Human zinc finger protein 627 (ZNF627)

RC209636L4 10 µg Ask for price

3`UTR clone of zinc finger protein 627 (ZNF627) for miRNA target validation

SC213599 10 µg Ask for price

ZNF627 (myc-DDK-tagged) - Human zinc finger protein 627 (ZNF627), transcript variant 2

RC238174 10 µg Ask for price

ZNF627 (myc-DDK-tagged) - Human zinc finger protein 627 (ZNF627), transcript variant 3

RC237653 10 µg Ask for price

ZNF627 (myc-DDK-tagged) - Human zinc finger protein 627 (ZNF627), transcript variant 4

RC237654 10 µg Ask for price

Lenti-ORF clone of ZNF627 (Myc-DDK-tagged)-Human zinc finger protein 627 (ZNF627)

RC209636L3 10 µg Ask for price

gp100 (619-627) (AA: Arg-Leu-Met-Lys-Gln-Asp-Phe-Ser-Val) (MW: 1123.35)

SP-88276-5 5 mg
EUR 270

Lenti ORF particles, ZNF627 (mGFP-tagged)-Human zinc finger protein 627 (ZNF627), 200ul, >10^7 TU/mL

RC209636L4V 200 µl Ask for price

Lenti ORF particles, ZNF627 (Myc-DDK-tagged)-Human zinc finger protein 627 (ZNF627), 200ul, >10^7 TU/mL

RC209636L3V 200 µl Ask for price

D10^627 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL507072V 500 ul each Ask for price

In contrast, silencing TRAF3 through adenoviruses worsened cartilage degradation in experimental OA. Moreover, the destructive effect of IL-17 on cartilage was abolished in T3TG mice in an IL-17 intra-articular (IA) injection animal model.